HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study.
Derek Pappas, Jill Hollenbach, Anne L Coleman, Michael B Gorin, Fe Yu, Kevin Williams, Janelle Noble, Gregory J Tranah, Study of Osteoporotic Fractures (SOF) Research Group
Article in Human immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 · What the graph read from it
What it found
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2 · The registry
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5 · Who and what money
Authors and funding
9 authors.
Derek PappasChildren's Hospital of Oakland Research Institute, Oakland, CA 94609, USA.
Jill HollenbachChildren's Hospital of Oakland Research Institute, Oakland, CA 94609, USA.
Anne L ColemanJules Stein Eye Institute and the UCLA Department of Ophthalmology, Los Angeles, CA 90095, USA.
Michael B GorinJules Stein Eye Institute and the UCLA Department of Ophthalmology, Los Angeles, CA 90095, USA.
Fe YuJules Stein Eye Institute and the UCLA Department of Ophthalmology, Los Angeles, CA 90095, USA.
Kevin WilliamsAtreca, Inc., San Carlos, CA 94070, USA.
Janelle NobleChildren's Hospital of Oakland Research Institute, Oakland, CA 94609, USA.
Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, CA 94107, USA. Electronic address: gtranah@sfcc-cpmc.net.
Study of Osteoporotic Fractures (SOF) Research Group
Funding
Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
Study of Osteoporotic FracturesR01AG005394 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1986 to 2015
$6.1M
STUDY OF OSTEOPOROTIC FRACTURES: VERTEBRAL FRACTURESR01AR035583 · NIAMS · KAISER FOUNDATION RESEARCH INSTITUTE · PI HILLIER, TERESA A · 1986 to 2005
$3.2M
Study of Osteoporotic Fractures (SOF)R01AG027574 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI HILLIER, TERESA A · 2006 to 2015
$2.6M
Study of Osteoporotic Fractures (SOF)-Pittsburgh ClinicR01AG027576 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2006 to 2015
$2.4M
Study of Osteoporotic FracturesR01AR035582 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE · 1986 to 2005
$2.4M
Study of Osteoporotic FracturesR01AR035584 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI HOCHBERG, MARC C. · 1986 to 2005
$2.1M
Immune Response Gene Polymorphisms and AMD: Examining HLA-KIR EpistasisR01EY019900 · NEI · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI TRANAH, GREGORY J. · 2010 to 2013
$1.8M
Integrated Exchange & Storage of Current and Future-Generation Immunogenomic DataR01GM109030 · NIGMS · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI HOLLENBACH, JILL ALLISON, MACK, STEVEN JOHN · 2014 to 2016
Multiple lines of evidence support an immunologic basis and genetic disposition for the development of age-related macular degeneration (AMD). Comprehensive human leukocyte antigens (HLA) class II typing at four loci (DRB1, DQA1, DQB1, and DPB1) was assessed using next generation sequencing methods and tested for association with age-related macular degeneration (AMD) in a case-control study of 456 AMD cases and 499 controls from the population-based Study of Osteoporotic Fractures (SOF) cohort. No statistically significant associations were identified for any of the class II loci and a previously identified association between DRB1*13:01 was not replicated in this dataset. These results reported here suggest that common HLA class II genetic variation does not contribute to AMD disease risk.
Indexed as
Population GroupsAgedAged, 80 and overCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHLA-DP beta-ChainsHLA-DQ alpha-ChainsHLA-DQ beta-ChainsHLA-DRB1 ChainsHumansMacular DegenerationMalePolymorphism, GeneticHLA-DPB1 antigenHLA-DP beta-ChainsHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DQB1 antigenHLA-DQ beta-ChainsHLA-DRB1 ChainsAge related macular degenerationAMDClass IIHLANext generation sequencing
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study. · full record | OpenQuestion