Evidence map›Paper›PMID 25665752›Full record

ArticleNeuroscience2015

Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice.

R A Altschuler, D F Dolan, K Halsey, A Kanicki, N Deng, C Martin, J Eberle, D C Kohrman, R A Miller, J Schacht

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 45 citations in OpenAlex.

  1. Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Article
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  6. Article
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  9. Pathology and mechanisms of cochlear aging.Journal of neuroscience research · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

R A AltschulerKresge Hearing Research Institute, Dept. of Otolaryngology, University of Michigan, Ann Arbor, MI, USA; Dept. of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
D F DolanKresge Hearing Research Institute, Dept. of Otolaryngology, University of Michigan, Ann Arbor, MI, USA.
K HalseyKresge Hearing Research Institute, Dept. of Otolaryngology, University of Michigan, Ann Arbor, MI, USA.
A KanickiKresge Hearing Research Institute, Dept. of Otolaryngology, University of Michigan, Ann Arbor, MI, USA.
N DengKresge Hearing Research Institute, Dept. of Otolaryngology, University of Michigan, Ann Arbor, MI, USA.
C MartinKresge Hearing Research Institute, Dept. of Otolaryngology, University of Michigan, Ann Arbor, MI, USA.
J EberleKresge Hearing Research Institute, Dept. of Otolaryngology, University of Michigan, Ann Arbor, MI, USA.
D C KohrmanKresge Hearing Research Institute, Dept. of Otolaryngology, University of Michigan, Ann Arbor, MI, USA; Dept. of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
R A MillerDept. of Pathology, University of Michigan, Ann Arbor, MI, USA.
J SchachtKresge Hearing Research Institute, Dept. of Otolaryngology, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · US

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Scientific Synergy CoreP30DC005188 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DOLAN, DAVID FRANCIS · 2002 to 2016
$10.3M
STRESS PATHWAYS IN THE AGING COCHLEAP01AG025164 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHACHT, JOCHEN · 2005 to 2009
$6.6M
GABA &GLYCINE IN THE AUDITORY BRAINSTEMR01DC000383 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALTSCHULER, RICHARD A · 1989 to 2006
$2.0M
NIA NIH HHS P01 AG025164NIA NIH HHS P01-AG025164NIA NIH HHS P30 AG024824NIA NIH HHS P30-AG024824NIDCD NIH HHS P30 DC005188NIDCD NIH HHS P30-DC05188NIDCD NIH HHS R01 DC000383
6 · The paper itself

Abstract

This study compared the timing of appearance of three components of age-related hearing loss that determine the pattern and severity of presbycusis: the functional and structural pathologies of sensory cells and neurons and changes in gap detection (GD), the latter as an indicator of auditory temporal processing. Using UM-HET4 mice, genetically heterogeneous mice derived from four inbred strains, we studied the integrity of inner and outer hair cells by position along the cochlear spiral, inner hair cell-auditory nerve connections, spiral ganglion neurons (SGN), and determined auditory thresholds, as well as pre-pulse and gap inhibition of the acoustic startle reflex (ASR). Comparisons were made between mice of 5-7, 22-24 and 27-29 months of age. There was individual variability among mice in the onset and extent of age-related auditory pathology. At 22-24 months of age a moderate to large loss of outer hair cells was restricted to the apical third of the cochlea and threshold shifts in the auditory brain stem response were minimal. There was also a large and significant loss of inner hair cell-auditory nerve connections and a significant reduction in GD. The expression of Ntf3 in the cochlea was significantly reduced. At 27-29 months of age there was no further change in the mean number of synaptic connections per inner hair cell or in GD, but a moderate to large loss of outer hair cells was found across all cochlear turns as well as significantly increased ABR threshold shifts at 4, 12, 24 and 48 kHz. A statistical analysis of correlations on an individual animal basis revealed that neither the hair cell loss nor the ABR threshold shifts correlated with loss of GD or with the loss of connections, consistent with independent pathological mechanisms.

Indexed as

AgingAnimalsAuditory PathwaysAuditory PerceptionAuditory ThresholdBrain-Derived Neurotrophic FactorCell CountCochlear NerveEvoked Potentials, Auditory, Brain StemFemaleGlial Cell Line-Derived Neurotrophic FactorHair Cells, Auditory, InnerHair Cells, Auditory, OuterMiceRandom AllocationReflex, StartleBrain-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic Factorage-related hearing lossagingauditorycochleagap detectionNT3

Identifiers

PMID25665752
PMCPMC4511166
OpenAlexW2053203160

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.