ArticleJournal of developmental origins of health and disease2015
The impact of prenatal parental tobacco smoking on risk of diabetes mellitus in middle-aged women.
Article in Journal of developmental origins of health and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Prenatal smoking exposure and cardio-metabolic risk factors in adulthood: a general population study and a meta-analysis.International journal of obesity (2005) · 2019Pooled it
- Grandmaternal perinatal serum polychlorinated biphenyls and prevalence of obesity in adult daughters and granddaughters.Obesity (Silver Spring, Md.) · 2025Article
- Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review.International journal of environmental research and public health · 2022Review
- Trends and burden of diabetes in pregnancy among Aboriginal and non-Aboriginal mothers in Western Australia, 1998-2015.BMC public health · 2022Article
- Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Pancreatic steatosis in adult rats induced by nicotine exposure during breastfeeding.Endocrine · 2021Article
- L-Leucine Improves Metabolic Disorders in Mice WithFrontiers in physiology · 2021Article
- In utero DDT exposure and breast density in early menopause by maternal history of breast cancer.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Smoking and pregnancy: Epigenetics and developmental origins of the metabolic syndrome.Birth defects research · 2019Review
- Cigarette Smoking, Diabetes, and Diabetes Complications: Call for Urgent Action.Current diabetes reports · 2017Review
- Developmental cigarette smoke exposure II: Hepatic proteome profiles in 6 month old adult offspring.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- Obesity, maternal smoking and SHBG in neonates.Diabetology & metabolic syndrome · 2016Article
- Digital Family History Data Mining with Neural Networks: A Pilot Study.Perspectives in health information managemen · 2016Article
- Parma consensus statement on metabolic disruptors.Environmental health : a global access science source · 2015Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Growing evidence indicates that parental smoking is associated with risk of offspring obesity. The purpose of this study was to identify whether parental tobacco smoking during gestation was associated with risk of diabetes mellitus. This is a prospective study of 44- to 54-year-old daughters (n = 1801) born in the Child Health and Development Studies pregnancy cohort between 1959 and 1967. Their mothers resided near Oakland California, were members of the Kaiser Foundation Health Plan and reported parental tobacco smoking during an early pregnancy interview. Daughters reported physician diagnoses of diabetes mellitus and provided blood samples for hemoglobin A1C measurement. Prenatal maternal smoking had a stronger association with daughters' diabetes mellitus risk than prenatal paternal smoking, and the former persisted after adjustment for parental race, diabetes and employment (aRR = 2.4 [95% confidence intervals 1.4-4.1] P < 0.01 and aRR = 1.7 [95% confidence intervals 1.0-3.0] P = 0.05, respectively). Estimates of the effect of parental smoking were unchanged when further adjusted by daughters' birth weight or current body mass index (BMI). Maternal smoking was also significantly associated with self-reported type 2 diabetes diagnosis (2.3 [95% confidence intervals 1.0-5.0] P < 0.05). Having parents who smoked during pregnancy was associated with an increased risk of diabetes mellitus among adult daughters, independent of known risk factors, providing further evidence that prenatal environmental chemical exposures independent of birth weight and current BMI may contribute to adult diabetes mellitus. While other studies seek to confirm our results, caution toward tobacco smoking by or proximal to pregnant women is warranted in diabetes mellitus prevention efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.