ArticlePLoS pathogens2015
Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting.
Article in PLoS pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- RT-QuIC optimization for prion detection in soils.MethodsX · 2025Article
- Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site.Prion · 2024Article
- Prion Seeding Activity in Plant Tissues Detected by RT-QuIC.Pathogens (Basel, Switzerland) · 2024Article
- Chronic Wasting Disease: State of the Science.Pathogens (Basel, Switzerland) · 2024Review
- New developments in prion disease research using genetically modified mouse models.Cell and tissue research · 2023Review
- Sensitive detection of chronic wasting disease prions recovered from environmentally relevant surfaces.Environment international · 2022Article
- Assessment of Real-Time Quaking-Induced Conversion (RT-QuIC) Assay, Immunohistochemistry and ELISA for Detection of Chronic Wasting Disease under Field Conditions in White-Tailed Deer: A Bayesian Approach.Pathogens (Basel, Switzerland) · 2022Article
- Prion Dissemination through the Environment and Medical Practices: Facts and Risks for Human Health.Clinical microbiology reviews · 2021Review
- Environmental and host factors that contribute to prion strain evolution.Acta neuropathologica · 2021Review
- Article
- Alteration of Prion Strain Emergence by Nonhost Factors.mSphere · 2019Article
- BSE infectivity survives burial for five years with only limited spread.Archives of virology · 2019Article
- Dehydration of Prions on Environmentally Relevant Surfaces Protects Them from Inactivation by Freezing and Thawing.Journal of virology · 2018Article
- The Ecology of Prions.Microbiology and molecular biology reviews : MMBR · 2017Review
- PrPSc formation and clearance as determinants of prion tropism.PLoS pathogens · 2017Article
- Objects in Contact with Classical Scrapie Sheep Act as a Reservoir for Scrapie Transmission.Frontiers in veterinary science · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Prions enter the environment from infected hosts, bind to a wide range of soil and soil minerals, and remain highly infectious. Environmental sources of prions almost certainly contribute to the transmission of chronic wasting disease in cervids and scrapie in sheep and goats. While much is known about the introduction of prions into the environment and their interaction with soil, relatively little is known about prion degradation and inactivation by natural environmental processes. In this study, we examined the effect of repeated cycles of drying and wetting on prion fitness and determined that 10 cycles of repeated drying and wetting could reduce PrP(Sc) abundance, PMCA amplification efficiency and extend the incubation period of disease. Importantly, prions bound to soil were more susceptible to inactivation by repeated cycles of drying and wetting compared to unbound prions, a result which may be due to conformational changes in soil-bound PrP(Sc) or consolidation of the bonding between PrP(Sc) and soil. This novel finding demonstrates that naturally-occurring environmental process can degrade prions.
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Registered trials
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