ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015
Tensile properties of craniofacial tendons in the mature and aged zebrafish.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Material properties of the embryonic small intestine during buckling morphogenesis.Acta biomaterialia · 2025Article
- The developmental mechanics of divergent buckling patterns in the chick gut.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Elastic fibers define embryonic tissue stiffness to enable buckling morphogenesis of the small intestine.Biomaterials · 2023Article
- Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions.International journal of molecular sciences · 2023Review
- Endogenous tenocyte activation underlies the regenerative capacity of the adult zebrafish tendon.NPJ Regenerative medicine · 2023Article
- ELASTIC FIBERS DEFINE EMBRYONIC TISSUE STIFFNESS TO ENABLE BUCKLING MORPHOGENESIS OF THE SMALL INTESTINE.bioRxiv : the preprint server for biology · 2023Article
- Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues.Nature biomedical engineering · 2023Article
- Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing.Connective tissue research · 2023Review
- The impact of Drew Noden's work on our understanding of craniofacial musculoskeletal integration.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Review
- Tendon Cell Regeneration Is Mediated by Attachment Site-Resident Progenitors and BMP Signaling.Current biology : CB · 2020Article
- Zebrafish: An Emerging Model for Orthopedic Research.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Zebrafish models of sarcopenia.Disease models & mechanisms · 2020Review
- Tendon Biomechanics and Crimp Properties Following Fatigue Loading Are Influenced by Tendon Type and Age in Mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Spatial Patterns and Age-Related Changes of the Collagen Crimp in the Human Cornea and Sclera.Investigative ophthalmology & visual science · 2018Article
- BMP signaling controls buckling forces to modulate looping morphogenesis of the gut.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Regenerative biology of tendon: mechanisms for renewal and repair.Current molecular biology reports · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The zebrafish Danio rerio is a powerful model for the study of development, regenerative biology, and human disease. However, the analysis of load-bearing tissues such as tendons and ligaments has been limited in this system. This is largely due to technical limitations that preclude accurate measurement of their mechanical properties. Here, we present a custom tensile testing system that applies nano-Newton scale forces to zebrafish tendons as small as 1 mm in length. Tendon properties were remarkably similar to mammalian tendons, including stress-strain nonlinearity and a linear modulus (515 ± 152 MPa) that aligned closely with mammalian data. Additionally, a simple exponential constitutive law used to describe tendon mechanics was successfully fit to zebrafish tendons; the associated material constants agreed with literature values for mammalian tendons. Finally, mature and aged zebrafish comparisons revealed a significant decline in mechanical function with age. Based on the exponential constitutive model, age-related changes were primarily caused by a reduction in nonlinearity (e.g., changes in collagen crimp or fiber recruitment). These findings demonstrate the utility of zebrafish as a model to study tendon biomechanics in health and disease. Moreover, these findings suggest that tendon mechanical behavior is highly conserved across vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.