Evidence map›Paper›PMID 25665055›Full record

ArticlePediatric research2015

Angiogenesis induced by prenatal ischemia predisposes to periventricular hemorrhage during postnatal mechanical ventilation.

Cigdem Tosun, Caron Hong, Brianna Carusillo, Svetlana Ivanova, Volodymyr Gerzanich, J Marc Simard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cigdem TosunDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Caron HongDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Brianna CarusilloDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Svetlana IvanovaDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Volodymyr GerzanichDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
J Marc Simard1] Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA [2] Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA [3] Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
University of Maryland, Baltimore · US

Funding

Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic strokeR01HL082517 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SIMARD, J. MARC · 2006 to 2021
$5.6M
Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subaraR01NS061808 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI SIMARD, J. MARC · 2009 to 2013
$1.6M
NHLBI NIH HHS HL082517NHLBI NIH HHS R01 HL082517NINDS NIH HHS NS061808NINDS NIH HHS R01 NS061808
6 · The paper itself

Abstract

backgroundThree risk factors are associated with hemorrhagic forms of encephalopathy of prematurity (EP): (i) prematurity, (ii) in utero ischemia (IUI) or perinatal ischemia, and (iii) mechanical ventilation. We hypothesized that IUI would induce an angiogenic response marked by activation of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9), the latter degrading vascular basement membrane and increasing vulnerability to raised intravenous pressure during positive pressure mechanical ventilation.

methodsWe studied a rat model of hemorrhagic-EP characterized by periventricular hemorrhages in which a 20-min episode of IUI is induced at E19, pups are born naturally at E21-22, and on P0, are subjected to a 20-min episode of positive pressure mechanical ventilation. Tissues were studied by H&E staining, immunolabeling, immunoblot, and zymography.

resultsMechanical ventilation of rat pups 2-3 d after 20-min IUI caused widespread hemorrhages in periventricular tissues. IUI resulted in upregulation of VEGF and MMP-9. Zymography confirmed significantly elevated gelatinase activity. MMP-9 activation was accompanied by severe loss of MMP-9 substrates, collagen IV and laminin, in microvessels in periventricular areas.

conclusionOur findings are consistent with the hypothesis that positive pressure mechanical ventilation of the newborn in the context of recent prenatal ischemia/hypoxia can predispose to periventricular hemorrhages.

Indexed as

Neovascularization, PathologicAnimalsBlood Gas AnalysisCollagen Type IVDisease Models, AnimalElectrolytesFemaleHemorrhageHypoxiaInflammationIntracranial HemorrhagesIschemiaLamininMaternal ExposureMatrix Metalloproteinase 9PregnancyCollagen Type IVElectrolytesLamininMatrix Metalloproteinase 9Mmp9 protein, ratVascular Endothelial Growth Factor Avascular endothelial growth factor A, rat

Identifiers

PMID25665055
PMCPMC4405433
OpenAlexW2059784593

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.