Evidence map›Paper›PMID 25665008›Full record

ArticleNature genetics2015

The genomic and phenotypic diversity of Schizosaccharomyces pombe.

Daniel C Jeffares, Charalampos Rallis, Adrien Rieux, Doug Speed, Martin Převorovský, Tobias Mourier, Francesc X Marsellach, Zamin Iqbal, Winston Lau, Tammy M K Cheng and 32 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The power of many: when genetics met yeasts and high-throughput.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  6. Article
  7. Gene loss, repression, amplification, and horizontal acquisition shape galactose/melibiose metabolism in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Proliferation and dissemination of killer meiotic drive loci.Current opinion in genetics & development · 2023
    Review
  19. The Fission Yeast Mating-Type Switching Motto: "One-for-Two" and "Two-for-One".Microbiology and molecular biology reviews : MMBR · 2023
    Review
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Daniel C JeffaresDepartment of Genetics, Evolution and Environment, University College London, London, UK.ORCID 0000000173200706
Charalampos RallisDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Adrien Rieux1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
Doug Speed1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
Martin PřevorovskýDepartment of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
Tobias MourierNatural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
Francesc X MarsellachDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Zamin IqbalWellcome Trust Centre for Human Genetics, Oxford, UK.
Winston LauDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Tammy M K ChengCell Cycle Laboratory, Cancer Research UK London Research Institute, London, UK.
Rodrigo PracanaDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Michael MüllederDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Jonathan L D Lawson1] Department of Genetics, University of Cambridge, Cambridge, UK. [2] Gurdon Institute, University of Cambridge, Cambridge, UK.
Anatole ChesselDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Sendu BalaWellcome Trust Sanger Institute, Cambridge, UK.
Garrett Hellenthal1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
Brendan O'FallonAssociated Regional and University Pathologists, Inc. University of Utah, Salt Lake City, Utah, USA.
Thomas KeaneWellcome Trust Sanger Institute, Cambridge, UK.
Jared T SimpsonWellcome Trust Sanger Institute, Cambridge, UK.
Leanne BischofCommonwealth Scientific and Industrial Research Organisation (CSIRO) Mathematics, Informatics and Statistics, North Ryde, New South Wales, Australia.
Bartlomiej TomiczekDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Danny A BittonDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Theodora SideriDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Sandra CodlinDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Josephine E E U HellbergDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Laurent van TrigtDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Linda JefferyCell Cycle Laboratory, Cancer Research UK London Research Institute, London, UK.
Juan-Juan LiCell Cycle Laboratory, Cancer Research UK London Research Institute, London, UK.
Sophie AtkinsonDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Malte ThodbergNatural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
Melanie FebrerGenome Analysis Centre, Norwich, UK.
Kirsten McLayGenome Analysis Centre, Norwich, UK.
Nizar DrouGenome Analysis Centre, Norwich, UK.
William BrownCentre for Genetics and Genomics, University of Nottingham, Nottingham, UK.
Jacqueline HaylesCell Cycle Laboratory, Cancer Research UK London Research Institute, London, UK.
Rafael E Carazo Salas1] Department of Genetics, University of Cambridge, Cambridge, UK. [2] Gurdon Institute, University of Cambridge, Cambridge, UK.ORCID 0000000259433981
Markus Ralser1] Department of Biochemistry, University of Cambridge, Cambridge, UK. [2] Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK. [3] Division of Physiology and Metabolism, Medical Research Council (MRC) National Institute for Medical Research, London, UK.ORCID 0000000195357413
Nikolas ManiatisDepartment of Genetics, Evolution and Environment, University College London, London, UK.
David J Balding1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.ORCID 0000000214806115
Francois Balloux1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.
Richard DurbinWellcome Trust Sanger Institute, Cambridge, UK.
Jürg Bähler1] Department of Genetics, Evolution and Environment, University College London, London, UK. [2] University College London Genetics Institute, University College London, London, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/H005854/1Biotechnology and Biological Sciences Research Council BB/H008802/1Biotechnology and Biological Sciences Research Council BB/K006320/1Cancer Research UK 15699European Research Council 260801European Research Council 260809Medical Research Council G0901388Medical Research Council MR/L012561/1Wellcome Trust 093735Wellcome Trust 093917Wellcome Trust 095598Wellcome Trust 095598/Z/11/ZWellcome Trust 098051Wellcome Trust 098386Wellcome Trust RG 093735/Z/10/Z
6 · The paper itself

Abstract

Natural variation within species reveals aspects of genome evolution and function. The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain. To extend the usefulness of this model, we surveyed the genomic and phenotypic variation in 161 natural isolates. We sequenced the genomes of all strains, finding moderate genetic diversity (π = 3 × 10(-3) substitutions/site) and weak global population structure. We estimate that dispersal of S. pombe began during human antiquity (∼340 BCE), and ancestors of these strains reached the Americas at ∼1623 CE. We quantified 74 traits, finding substantial heritable phenotypic diversity. We conducted 223 genome-wide association studies, with 89 traits showing at least one association. The most significant variant for each trait explained 22% of the phenotypic variance on average, with indels having larger effects than SNPs. This analysis represents a rich resource to examine genotype-phenotype relationships in a tractable model.

Indexed as

Genome, FungalGenetic VariationGenome-Wide Association StudyGenomicsGenotypeHumansPhenotypePolymorphism, Single NucleotideSchizosaccharomyces

Identifiers

PMID25665008
PMCPMC4645456

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.