ArticleChannels (Austin, Tex.)2015
A new genetic model for calcium induced autophagy and ER-stress in Drosophila photoreceptor cells.
Article in Channels (Austin, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Aging and Light Stress Result in Overlapping and Unique Gene Expression Changes in Photoreceptors.Genes · 2022Article
- Changes in endolysosomal organization define a pre-degenerative state in the crumbs mutant Drosophila retina.PloS one · 2019Article
- Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors.BMC neuroscience · 2018Article
- Regulated Alternative Splicing ofGenetics · 2018Article
- Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration.NPJ aging and mechanisms of disease · 2017Article
- LncRNA mediated regulation of aging pathways inAging · 2016Article
- Ire1 supports normal ER differentiation in developing Drosophila photoreceptors.Journal of cell science · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Cytoplasmic Ca2+ overload is known to trigger autophagy and ER-stress. Furthermore, ER-stress and autophagy are commonly associated with degenerative pathologies, but their role in disease progression is still a matter of debate, in part, owing to limitations of existing animal model systems. The Drosophila eye is a widely used model system for studying neurodegenerative pathologies. Recently, we characterized the Drosophila protein, Calphotin, as a cytosolic immobile Ca2+ buffer, which participates in Ca2+ homeostasis in Drosophila photoreceptor cells. Exposure of calphotin hypomorph flies to continuous illumination, which induces Ca2+ influx into photoreceptor cells, resulted in severe Ca2+-dependent degeneration. Here we show that this degeneration is autophagy and ER-stress related. Our studies thus provide a new model in which genetic manipulations trigger changes in cellular Ca2+ distribution. This model constitutes a framework for further investigations into the link between cytosolic Ca2+, ER-stress and autophagy in human disorders and diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.