ArticleNature neuroscience2015
In vivo coincidence detection in mammalian sound localization generates phase delays.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Binaural Processing Deficits in Autism Spectrum Disorder.Audiology research · 2026Review
- Bridged artificial neurons based on memristor circuit for spiking propagation network and coincidence detection.iScience · 2026Article
- Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.Journal of computational neuroscience · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Electrophysiological correlates of divergent projections in the avian superior olivary nucleus.Journal of neurophysiology · 2024Article
- Coincidence detection and integration behavior in spiking neural networks.Cognitive neurodynamics · 2024Article
- Dynamics of interaction betweenCognitive neurodynamics · 2024Article
- Developmental fine-tuning of medial superior olive neurons mitigates their predisposition to contralateral sound sources.PLoS biology · 2024Article
- Sound processing in the cricket brain: evidence for a pulse duration filter.Journal of neurophysiology · 2023Article
- Somatic Integration of Incoherent Dendritic Inputs in the Gerbil Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Structure and dynamics that specialize neurons for high-frequency coincidence detection in the barn owl nucleus laminaris.Biological cybernetics · 2023Article
- Geometric characterization of dynamical structure for neural firing activities induced by inhibitory pulse.Cognitive neurodynamics · 2022Article
- Mammalian octopus cells are direction selective to frequency sweeps by excitatory synaptic sequence detection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.Frontiers in synaptic neuroscience · 2022Review
- Predicting the Influence of Axon Myelination on Sound Localization Precision Using a Spiking Neural Network Model of Auditory Brainstem.Frontiers in neuroscience · 2022Article
- Dendritic synapse geometry optimizes binaural computation in a sound localization circuit.Science advances · 2021Article
- Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity.eLife · 2021Article
- Auditory Brainstem Models: Adapting Cochlear Nuclei Improve Spatial Encoding by the Medial Superior Olive in Reverberation.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Arrangement of Excitatory Synaptic Inputs on Dendrites of the Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
Sound localization critically depends on detection of differences in arrival time of sounds at the two ears (acoustic delay). The fundamental mechanisms are debated, but all proposals include a process of coincidence detection and a separate source of internal delay that offsets the acoustic delay and determines neural tuning. We used in vivo patch-clamp recordings of binaural neurons in the Mongolian gerbil and pharmacological manipulations to directly compare neuronal input to output and to separate excitation from inhibition. Our results cannot be accounted for by existing models and reveal that coincidence detection is not an instantaneous process, but is instead shaped by the interaction of intrinsic conductances with preceding synaptic activity. This interaction generates an internal delay as an intrinsic part of the process of coincidence detection. The multiplication and time-shifting stages thought to extract synchronous activity in many brain areas can therefore be combined in a single operation.
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