ArticlePloS one2015
Characterization of foot-and-mouth disease viruses (FMDVs) from Ugandan cattle outbreaks during 2012-2013: evidence for circulation of multiple serotypes.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Prioritizing smallholder animal health needs in East Africa, West Africa, and South Asia using three approaches: Literature review, expert workshops, and practitioner surveys.Preventive veterinary medicine · 2021Pooled it
- Performance of prototype serological immunoassays for foot-and-mouth disease virus using G-H loop peptides and stabilized virus-like particles.Microbiology spectrum · 2026Article
- Participation of livestock farmers and community animal health workers in one health intervention to control zoonotic diseases in Rwanda: a qualitative study.BMC infectious diseases · 2026Article
- Spatial Patterns and Epidemiological Drivers of Foot-and-Mouth Disease Outbreaks in Uganda.Transboundary and emerging diseases · 2026Article
- Epidemiology of Foot-and-Mouth Disease in Goats in Uganda: A Risk-Based Approach.Transboundary and emerging diseases · 2026Article
- Near complete genome sequences of 12 foot-and-mouth disease viruses of serotype O, isolated from cattle in eastern and northern Uganda between 2014 and 2017.Microbiology resource announcements · 2025Article
- Molecular characterization and epidemiological insights into serotypes of foot-and-mouth disease virus in Pakistan.Archives of virology · 2025Article
- Sero-Prevalence of Foot-and-Mouth Disease in Cattle in Selected Districts of Jimma Zone, South-Western Ethiopia.Veterinary medicine and science · 2025Article
- Analysis of patterns of livestock movements in the Cattle Corridor of Uganda for risk-based surveillance of infectious diseases.Frontiers in veterinary science · 2023Article
- Complete Coding Genome Sequences of Five Foot-and-Mouth Disease Viruses Belonging to Serotype O, Isolated from Cattle in Uganda in 2015 to 2016.Microbiology resource announcements · 2022Article
- Outbreaks of Foot-and-Mouth Disease in Burundi, East Africa, in 2016, Caused by Different Serotypes.Viruses · 2022Article
- Seroprevalence of bovine foot and mouth disease (FMD) and its associated risk factors in selected districts of Afar region, Ethiopia.Veterinary medicine and science · 2021Article
- Article
- Seroprevalence and Molecular Detection of Foot and Mouth Disease Virus in Dairy Cattle Around Addis Ababa, Central Ethiopia.Veterinary medicine (Auckland, N.Z.) · 2021Article
- Impact of truck contamination and information sharing on foot-and-mouth disease spreading in beef cattle production systems.PloS one · 2020Article
- Genetic Diversity of Circulating Foot and Mouth Disease Virus in Uganda Cross-Sectional Study During 2014-2017.Frontiers in veterinary science · 2020Article
- Co-infection with different serotypes of FMDV in vaccinated cattle in Southern Egypt.Virus genes · 2019Article
- Low topotype diversity of recent foot-and-mouth disease virus serotypes O and A from districts located along the Uganda and Tanzania border.Journal of veterinary science · 2019Article
- Spatial and temporal distribution of foot-and-mouth disease in four districts situated along the Uganda-Tanzania border: Implications for cross-border efforts in disease control.The Onderstepoort journal of veterinary research · 2018Article
- A traditional evolutionary history of foot-and-mouth disease viruses in Southeast Asia challenged by analyses of non-structural protein coding sequences.Scientific reports · 2018Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the foot-and-mouth disease virus (FMDV) serotypes circulating in Uganda's cattle population, both serological and virological analyses of samples from outbreaks that occurred during 2012-2013 were performed. Altogether, 79 sera and 60 oropharyngeal fluid (OP)/tissue/oral swab samples were collected from herds with reported FMD outbreaks in seven different Ugandan districts. Overall, 61/79 (77%) of the cattle sera were positive for antibodies against FMDV by PrioCHECK FMDV NS ELISA and solid phase blocking ELISA detected titres ≥ 80 for serotypes O, SAT 1, SAT 2 and SAT 3 in 41, 45, 30 and 45 of these 61 seropositive samples, respectively. Virus neutralisation tests detected the highest levels of neutralising antibodies (titres ≥ 45) against serotype O in the herds from Kween and Rakai districts, against SAT 1 in the herd from Nwoya district and against SAT 2 in the herds from Kiruhura, Isingiro and Ntungamo districts. The isolation of a SAT 2 FMDV from Isingiro was consistent with the detection of high levels of neutralising antibodies against SAT 2; sequencing (for the VP1 coding region) indicated that this virus belonged to lineage I within this serotype, like the currently used vaccine strain. From the Wakiso district 11 tissue/swab samples were collected; serotype A FMDV, genotype Africa (G-I), was isolated from the epithelial samples. This study shows that within a period of less than one year, FMD outbreaks in Uganda were caused by four different serotypes namely O, A, SAT 1 and SAT 2. Therefore, to enhance the control of FMD in Uganda, there is need for efficient and timely determination of outbreak virus strains/serotypes and vaccine matching. The value of incorporating serotype A antigen into the imported vaccines along with the current serotype O, SAT 1 and SAT 2 strains should be considered.
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