ArticleActa crystallographica. Section D, Biological crystallography2015
Data Exploration Toolkit for serial diffraction experiments.
Article in Acta crystallographica. Section D, Biological crystallography, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Enhanced intensity-based clustering of isomorphous multi-crystal data sets in the presence of subtle variations.Acta crystallographica. Section D, Structural biology · 2025Article
- Serial-femtosecond crystallography reveals how a phytochrome variant couples chromophore and protein structural changes.Science advances · 2025Article
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- Structure of a ribonucleotide reductase R2 protein radical.Science (New York, N.Y.) · 2023Article
- Sample Preparation for Time-Resolved Serial Crystallography: Practical Considerations.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Serial crystallography with multi-stage merging of thousands of images.Acta crystallographica. Section F, Structural biology communications · 2022Article
- xia2.multiplex: a multi-crystal data-analysis pipeline.Acta crystallographica. Section D, Structural biology · 2022Article
- Best practices for high data-rate macromolecular crystallography (HDRMX).Structural dynamics (Melville, N.Y.) · 2020Article
- Article
- A space for lattice representation and clustering.Acta crystallographica. Section A, Foundations and advances · 2019Article
- How best to use photons.Acta crystallographica. Section D, Structural biology · 2019Article
- Fast and accurate data collection for macromolecular crystallography using the JUNGFRAU detector.Nature methods · 2018Article
- Determination of Patterson group symmetry from sparse multi-crystal data sets in the presence of an indexing ambiguity.Acta crystallographica. Section D, Structural biology · 2018Article
- Article
- TakeTwo: an indexing algorithm suited to still images with known crystal parameters.Acta crystallographica. Section D, Structural biology · 2016Article
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- Article
- Recent developments inJournal of applied crystallography · 2016Article
- In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.Acta crystallographica. Section D, Structural biology · 2016Article
- Article
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10 authors.
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Abstract
Ultrafast diffraction at X-ray free-electron lasers (XFELs) has the potential to yield new insights into important biological systems that produce radiation-sensitive crystals. An unavoidable feature of the `diffraction before destruction' nature of these experiments is that images are obtained from many distinct crystals and/or different regions of the same crystal. Combined with other sources of XFEL shot-to-shot variation, this introduces significant heterogeneity into the diffraction data, complicating processing and interpretation. To enable researchers to get the most from their collected data, a toolkit is presented that provides insights into the quality of, and the variation present in, serial crystallography data sets. These tools operate on the unmerged, partial intensity integration results from many individual crystals, and can be used on two levels: firstly to guide the experimental strategy during data collection, and secondly to help users make informed choices during data processing.
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