Evidence map›Paper›PMID 25664725›Full record

ArticleNature structural & molecular biology2015

Exon-intron circular RNAs regulate transcription in the nucleus.

Zhaoyong Li, Chuan Huang, Chun Bao, Liang Chen, Mei Lin, Xiaolin Wang, Guolin Zhong, Bin Yu, Wanchen Hu, Limin Dai and 8 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1,819 papers.

0numbers the graph read from it
0cells of the map it votes in
1,819citing papers in PubMed
73.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,819 citing papers in PubMed, 3,018 citations in OpenAlex.

  1. Review
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  7. Circular RNAs in ferroptosis regulation and tumor progression of gynecological and breast cancers: molecular mechanisms and therapeutic potential.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  8. Genome stability disrupted by the circRBM39(4,5,6)-RPA2 axis represses breast tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  20. Special Issue "Epigenetic Genes, Biomarkers and Immunotherapy in Cancers".International journal of molecular sciences · 2026
    Article

1,759 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Zhaoyong Li1] School of Life Sciences, University of Science and Technology of China, Hefei, China. [2] Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
Chuan HuangSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Chun Bao1] School of Life Sciences, University of Science and Technology of China, Hefei, China. [2] Department of Physics, Central China Normal University, Wuhan, China. [3] Institute of Biophysics, Central China Normal University, Wuhan, China.
Liang ChenSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Mei LinSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Xiaolin WangSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Guolin ZhongSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Bin YuSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Wanchen HuSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Limin DaiSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Pengfei ZhuSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Zhaoxia ChangSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Qingfa WuSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Yi ZhaoInstitute of Computing Technology, Chinese Academy of Sciences, Beijing, China.
Ya Jia1] Department of Physics, Central China Normal University, Wuhan, China. [2] Institute of Biophysics, Central China Normal University, Wuhan, China.
Ping XuNational Center for Protein Sciences, Beijing, China.
Huijie LiuSchool of Life Sciences, University of Science and Technology of China, Hefei, China.
Ge Shan1] School of Life Sciences, University of Science and Technology of China, Hefei, China. [2] Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, China.
University of Science and Technology of China · CNCentral China Normal University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of the prominent roles is to regulate gene expression. A vast number of circular RNAs (circRNAs) have been identified, and some have been shown to function as microRNA sponges in animal cells. Here, we report a class of circRNAs associated with RNA polymerase II in human cells. In these circRNAs, exons are circularized with introns 'retained' between exons; we term them exon-intron circRNAs or EIciRNAs. EIciRNAs predominantly localize in the nucleus, interact with U1 snRNP and promote transcription of their parental genes. Our findings reveal a new role for circRNAs in regulating gene expression in the nucleus, in which EIciRNAs enhance the expression of their parental genes in cis, and highlight a regulatory strategy for transcriptional control via specific RNA-RNA interaction between U1 snRNA and EIciRNAs.

Indexed as

Gene Expression RegulationBase SequenceExonsHEK293 CellsHeLa CellsHumansIntronsModels, GeneticModels, MolecularMolecular Sequence DataNucleic Acid ConformationRNA Polymerase IIRNA, UntranslatedSequence Analysis, RNARNA Polymerase IIRNA, Untranslated

Identifiers

PMID25664725
OpenAlexW1966411071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.