ArticleBehavioral neuroscience2015
Neural correlates of impulsive aggressive behavior in subjects with a history of alcohol dependence.
Article in Behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Prefrontal TDCS does not improve working memory performance in individuals with chronic alcohol and tobacco use.IBRO neuroscience reports · 2026Article
- Dissecting different forms of impulsivity and its relationships to anxiety in the link between alcohol dependence and aggression among Chinese male alcohol-dependent patients.SAGE open medicine · 2025Article
- Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence.Brain imaging and behavior · 2024Article
- The cerebellum during provocation and aggressive behaviour: A 7 T fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Morphology of the criminal brain: gray matter reductions are linked to antisocial behavior in offenders.Brain structure & function · 2020Article
- Anger provocation increases limbic and decreases medial prefrontal cortex connectivity with the left amygdala in reactive aggressive violent offenders.Brain imaging and behavior · 2019Article
- Habenula-prefrontal resting-state connectivity in reactive aggressive men - A pilot study.Neuropharmacology · 2019Article
- Physical Activity in Natural Environments Is Associated With Motivational Climate and the Prevention of Harmful Habits: Structural Equation Analysis.Frontiers in psychology · 2019Article
- An Eye for an Eye: Neural Correlates of the Preference for Punishment-Based Justice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The neural correlates of alcohol-related aggression.Cognitive, affective & behavioral neuroscience · 2018Article
- Aggression in Women: Behavior, Brain and Hormones.Frontiers in behavioral neuroscience · 2018Review
- Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI andNeuropsychiatric disease and treatment · 2017Article
- Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study.NeuroImage. Clinical · 2017Article
- Hit or Run: Exploring Aggressive and Avoidant Reactions to Interpersonal Provocation Using a Novel Fight-or-Escape Paradigm (FOE).Frontiers in behavioral neuroscience · 2017Article
- Wheel running reduces ethanol seeking by increasing neuronal activation and reducing oligodendroglial/neuroinflammatory factors in the medial prefrontal cortex.Brain, behavior, and immunity · 2016Article
- Reward vs. Retaliation-the Role of the Mesocorticolimbic Salience Network in Human Reactive Aggression.Frontiers in behavioral neuroscience · 2016Article
- The effect of HD-tDCS on brain oscillations and frontal synchronicity during resting-state EEG in violent offenders with a substance dependence.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Alcohol-related aggression is a complex and problematic phenomenon with profound public health consequences. We examined neural correlates potentially moderating the relationship between human aggressive behavior and chronic alcohol use. Thirteen subjects meeting DSM-IV criteria for past alcohol-dependence in remission (AD) and 13 matched healthy controls (CONT) participated in an fMRI study adapted from a laboratory model of human aggressive behavior (Point Subtraction Aggression Paradigm, or PSAP). Blood oxygen level dependent (BOLD) activation was measured during bouts of operationally defined aggressive behavior, during postprovocation periods, and during monetary-reinforced behavior. Whole brain voxelwise random-effects analyses found group differences in brain regions relevant to chronic alcohol use and aggressive behavior (e.g., emotional and behavioral control). Behaviorally, AD subjects responded on both the aggressive response and monetary response options at significantly higher rates than CONT. Whole brain voxelwise random-effects analyses revealed significant group differences in response to provocation (monetary subtractions), with CONT subjects showing greater activation in frontal and prefrontal cortex, thalamus, and hippocampus. Collapsing data across all subjects, regression analyses of postprovocation brain activation on aggressive response rate revealed significant positive regression slopes in precentral gyrus and parietal cortex; and significant negative regression slopes in orbitofrontal cortex, prefrontal cortex, caudate, thalamus, and middle temporal gyrus. In these collapsed analyses, response to provocation and aggressive behavior were associated with activation in brain regions subserving inhibitory and emotional control, sensorimotor integration, and goal directed motor activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.