Evidence map›Paper›PMID 25664140›Full record

ArticleInternational journal of clinical and experimental medicine2014

Role of microRNAs in diagnosis and treatment of the pathogenesis of gastric cancer.

Gang Chen, Yong Tang, Jiang-Hua Wu, Feng-Hua Liu

RetractedOpen access · greenAbstract readRetracted Publication
In one paragraph

Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
  7. Dysregulation of non-coding RNAs in gastric cancer.World journal of gastroenterology · 2015
    Review
  8. Long-term follow-up after laparoscopic versus open distal gastrectomy for advanced gastric cancer.International journal of clinical and experimental medicine · 2015
    Article
  9. MiR-451, a potential prognostic biomarker and tumor suppressor for gastric cancer.International journal of clinical and experimental pathology · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gang ChenDepartment of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University Wuhan, China.
Yong TangDepartment of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University Wuhan, China.
Jiang-Hua WuDepartments of Gynecological Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital Tianjin, China.
Feng-Hua LiuDepartments of Gynecological Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital Tianjin, China.
Tianjin Medical University Cancer Institute and Hospital · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aim to detect the miRNAs that are correlated with the gastric cancer cell line SGC-7901 to provide theoretical basis for clinical application. We first analyzed miRNA expression profiles of gastric cancer patients compared with normal controls by microarray analysis and validated the results by real-time qPCR. We also determined the absolute copy numbers of these three miRNAs in normal adults. The results showed that three miRNAs (miR-150, miR-23a, and miR-130a) were identified to significantly decrease in expanded 38 gastric cancer patients compared with 90 normal controls. Molecular and statistical analysis showed that the decreased miRNAs were significant in clinical analysis. Generally speaking, this finding suggest vital roles of these miRNAs in human gastric cancer genesis and as potential biomarkers in gastric cancer diagnosis.

Indexed as

diagnosis biomarkergastric cancermicroRNAsSGC-7901

Identifiers

PMID25664140
PMCPMC4307587
OpenAlexW148451429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.