Evidence map›Paper›PMID 25664048›Full record

ArticleInternational journal of clinical and experimental medicine2014

Association of TBX2 and P21 expression with clinicopathological features and survival of laryngeal squamous cell carcinoma.

Yongjiu Huang, Zufei Li, Qi Zhong, Guojun Li, Yang Zhang, Zhigang Huang

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

0.6field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression.Oncology letters · 2024
Article
T-box 2 expression is a useful indicator of the response to neoadjuvant chemotherapy for patients with locally advanced uterine cervical squamous cell carcinoma.Oncology letters · 2021
Article
lncRNA IGKJ2-MALLP2 suppresses LSCC proliferation, migration, invasion, and angiogenesis by sponging miR-1911-3p/p21.Cancer science · 2020
Article
TBX2 overexpression promotes proliferation and invasion through epithelial-mesenchymal transition and ERK signaling pathway.Experimental and therapeutic medicine · 2019
Article
TBX2 expression is associated with platinum-sensitivity of ovarian serous carcinoma.Oncology letters · 2018
Article
Tbx2 confers poor prognosis in glioblastoma and promotes temozolomide resistance with change of mitochondrial dynamics.OncoTargets and therapy · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yongjiu HuangDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.

Zufei LiDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.

Qi ZhongDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.

Guojun LiDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.

Yang ZhangDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.

Zhigang HuangDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.

Capital University · USThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe expression of P21 and TBX2 in laryngeal squamous cell carcinoma (LSCC) and their corresponding adjacent normal laryngeal tissues, as well as their association with clinical pathological features and survival remain unclear.

methodwe used the RT-PCR and immunohistochemistry to detect their mRNA and protein levels in 75 LSCC patients. We also use log-rank test and Cox models to compare survival among different groups.

resultsThe mRNA expression level of TBX2 was up-regulated, while P21 was down-regulated in LSCC compared with their matched adjacent laryngeal tissues (All P < 0.001). The expression of P21 was correlated with tumor stage, lymph node metastasis and smoking; and TBX2 expression was associated with lymph node metastasis, differentiation degree and smoking (All P < 0.05). Patients with high TBX2 and low P21 expression had significantly worse survival than those with low TBX2 and high P21 expression, respectively (All P < 0.05). A significant correlation between expression of TBX2 and P21 (Pearson, P < 0.05) was observed. Furthermore, multivariable analysis showed that patients with low TBX2 and high P21 expression alone had a significantly reduced risk for overall death compared with those with low TBX2 and high P21 expression. The risk for overall death was even lower for patients with both low and high expression of both genes than any other co-expression status of both genes (HR, 0.1; 95% CI, 0.0-0.9).

conclusionThese results suggest that abnormal expression of P21 and TBX2 in tumors may jointly, or individually, predict poor prognosis of LSCC.

Indexed as

LSCCP21survivalTBX2

Identifiers

PMID25664048

PMCPMC4307495

OpenAlexW2407304875

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.