TLR4 +896A>G (Asp299Gly) polymorphism is not associated with asthma: a update meta-analysis.

Yingshui Yao, Xiaohua Ren, Lianping He, Jie Li, Yuelong Jin, Weiwei Chang, Chaopin Li

Abstract read

In one paragraph

Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

Association of TLR4 (896A/G and 1196C/T) Gene Polymorphisms with Asthma Risk: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
Pooled it
Dual Role of Toll-like Receptors in Human and Experimental Asthma Models.Frontiers in immunology · 2018
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yingshui YaoLaboratory of Environment and Health, School of Earth and Environment, Anhui University of Science and Technology Huainan 232001, China ; School of Public Health, Wannan Medical College Wuhu 241002, China.

Xiaohua RenSchool of Public Health, Wannan Medical College Wuhu 241002, China.

Lianping HeSchool of Public Health, Wannan Medical College Wuhu 241002, China.

Jie LiSchool of Public Health, Wannan Medical College Wuhu 241002, China.

Yuelong JinSchool of Public Health, Wannan Medical College Wuhu 241002, China.

Weiwei ChangSchool of Public Health, Wannan Medical College Wuhu 241002, China.

Chaopin LiLaboratory of Environment and Health, School of Earth and Environment, Anhui University of Science and Technology Huainan 232001, China ; Department of Medical Parasitology, Wannan Medical College Wuhu 241002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some research reported that polymorphisms in the toll-Like receptor 4 may have influence on asthma risk. Here, we sought to estimate the effects of Toll-Like Receptor 4 (Asp299Gly) genes on asthma risk. Databases including PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched to find relevant studies. The odds ratio (OR) with corresponding 95% confidence intervals (CIs) was performed. A total of 12 case-control studies were finally identified. This meta-analysis indicated that no significant association was found between TLR4 (Asp299Gly) genes and asthma risk (OR = 0.91, 95% CI = 0.71-1.12). In conclusion, our findings suggest that TLR4 +896A>G (Asp299Gly) polymorphism may not contribute to the risk of asthma.

Indexed as

asthmameta-analysispolymorphismsingle nucleotide polymorphismToll-Like Receptor 4

Identifiers

PMID25664044

PMCPMC4307491

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.