ArticleInternational journal of clinical and experimental medicine2014
Atorvastatin ameliorates myocardial ischemia/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- The Impact of Opioids on Epigenetic Modulation in Myocardial Ischemia and Reperfusion Injury: Focus on Non-coding RNAs.Journal of cardiovascular translational research · 2025Review
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- Combination drug therapy prevents CIAKI by suppressing ER stress-induced apoptosis.Scientific reports · 2024Article
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- Tilianin extracted from Xiangqinglan () inhibits apoptosis induced by mitochondrial pathway and endoplasmic reticulum stress in H9c2 cells after oxygen-glucose deprivation/reoxygenation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model.Frontiers in cardiovascular medicine · 2022Article
- Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases.Nature reviews. Cardiology · 2021Review
- Silencing RNF13 Alleviates Parkinson's Disease - Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress-Mediated IRE1α-TRAF2-ASK1-JNK Pathway.Journal of molecular neuroscience : MN · 2020Article
- Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways.Toxicology reports · 2020Article
- Sigma-1 receptor protects against endoplasmic reticulum stress-mediated apoptosis in mice with cerebral ischemia/reperfusion injury.Apoptosis : an international journal on programmed cell death · 2019Article
- Xin-Ji-Er-Kang Alleviates Myocardial Infarction-Induced Cardiovascular Remodeling in Rats by Inhibiting Endothelial Dysfunction.BioMed research international · 2019Article
- Lycium barbarum polysaccharide arbitrates palmitate-induced apoptosis in MC3T3‑E1 cells through decreasing the activation of ERS‑mediated apoptosis pathway.Molecular medicine reports · 2018Article
- Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1α and PERK signaling activation.Molecular and cellular biochemistry · 2017Article
- Rhizoma Coptidis: A Potential Cardiovascular Protective Agent.Frontiers in pharmacology · 2016Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endoplasmic reticulum stress (ERS) is known to play an important role in mediating myocardial ischemic/reperfusion (I/R) injury. Some previous studies have shown that atorvastatin alleviates myocardial I/R injury in animal models, but whether attenuation of ERS-induced apoptosis contributes to this effect remains to be elucidated. Therefore, in this study, we sought to investigate the modulatory effect of atorvastatin on myocardial I/R-induced ERS in rats. Myocardial I/R injury was induced in rats by occlusion of the left anterior descending coronary artery (LAD) for 0.5 h followed by 2 h of reperfusion. Atorvastatin was administered at different dosages (10 mg/kg, 20 mg/kg, and 40 mg/kg) at the onset of reperfusion. The levels of the CK-MB and LDH were detected by ELISA. Myocardial ischemia and infarct size were evaluated by Evans blue and tetrazolium chloride (TTC) staining. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was used to investigate myocardial cell apoptosis. The expression levels of the genes encoding glucose-regulated protein-78 (GRP78, widely used as a marker of ERS), C/EBP homologous protein (CHOP) and caspase-12 (widely used as markers of ERS-induced apoptosis) were assessed using RT-PCR. The expression levels of the ERS proteins GRP78, CHOP, caspase-12, c-Jun NH2 terminal kinase (JNK) and phosphorylated JNK (p-JNK) were detected by western blot. Our results showed that atorvastatin treatment (20 mg/kg and 40 mg/kg) significantly reduced myocardial infarct size and myocardial cell apoptosis, and decreased the plasma levels of CK-MB and LDH in I/R rats. This treatment also significantly modulated mRNA and protein levels, specifically down-regulating GRP78, CHOP and caspase-12 expression along with JNK activation. These results suggest that the attenuation of ERS-induced apoptosis may be involved in the cardioprotective mechanisms of atorvastatin in myocardial I/R injury.
Indexed as
Identifiers
25663988PMC4307435W2402251440What OpenQuestion holds
Registered trials
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