Evidence map›Paper›PMID 25663771›Full record

ArticleWorld journal of gastroenterology2015

CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan.

Ping Li, Xu-Dong Tang, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ping LiPing Li, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Xu-Dong TangPing Li, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Zheng-Xu CaiPing Li, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Juan-Juan QiuPing Li, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Xue-Lian LinPing Li, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Tong ZhuPing Li, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Lawrence OwusuPing Li, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Hui-Shu GuoPing Li, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the distribution and expression of C-type natriuretic peptide (CNP)/natriuretic peptide receptor B (NPR-B) in the rectum of a rodent depression model and the interventional effect of Xiaoyaosan (XYS).

methodsMale rats (n = 45) of clean grade (200 ± 20 g) were divided into five groups after one week of adaptive feeding: primary control, depression model, low dose XYS, middle dose XYS, and high dose XYS. The animal experiment continued for 3 wk. Primary controls were fed normally ad libitum. The rats of all other groups were raised in solitary and exposed to classic chronic mild unpredictable stimulation each day. XYS groups were perfused intragastrically with low dose, middle dose, and high dose XYS one hour before stimulation. Primary control and depression model groups were perfused intragastrically with normal saline under similar conditions as the XYS groups. Three weeks later, all rats were sacrificed, and the expression levels of CNP and NPR-B in rectum tissues were analyzed by immunohistochemistry, real-time polymerase chain reaction, and Western blotting.

resultsCNP and NPR-B were both expressed in the rectum tissues of all rats. However, the expression levels of CNP and NPR-B at both gene and protein levels in the depression model group were significantly higher when compared to the primary control group (n = 9; P < 0.01). XYS intervention markedly inhibited the expression levels of CNP and NPR-B in depressed rats. The expression levels of CNP and NPR-B in the high dose XYS group did not significantly differ from the expression levels in the primary control group. Additionally, the high and middle dose XYS groups (but not the low dose group) significantly exhibited lower CNP and NPR-B expression levels in the rectum tissues of the respectively treated rats compared to the untreated depression model cohort (n = 9; P < 0.01).

conclusionThe CNP/NPR-B pathway is upregulated in the rectum of depressed rats and may be one mechanism for depression-associated digestive disorders. XYS antagonizes this pathway at least partially.

Indexed as

AnimalsAntidepressive AgentsAtrial Natriuretic Factor Receptor BBehavior, AnimalDepressionDisease Models, AnimalDose-Response Relationship, DrugDrugs, Chinese HerbalMaleNatriuretic Peptide, C-TypeRats, Sprague-DawleyReceptors, Atrial Natriuretic FactorRectumRNA, MessengerSignal TransductionTime FactorsAntidepressive AgentsAtrial Natriuretic Factor Receptor BDrugs, Chinese HerbalNatriuretic Peptide, C-TypeReceptors, Atrial Natriuretic FactorRNA, MessengerxiaoyaosanC-Type natriuretic peptideDepressionGastrointestinal motilityNatriuretic peptide receptor type BRectum

Identifiers

PMID25663771
PMCPMC4316094
OpenAlexW2317521207

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.