Evidence map›Paper›PMID 25663731›Full record

ArticleApplied surface science2014

Silane surface modification for improved bioadhesion of esophageal stents.

Mert Karakoy, Evin Gultepe, Shivendra Pandey, Mouen A Khashab, David H Gracias

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied surface science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. A simplified technique of esophageal self-expandable metallic stent placement without fluoroscopic and endoscopic guidance for treating esophageal carcinoma.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mert KarakoyDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
Evin GultepeDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
Shivendra PandeyDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
Mouen A KhashabDivision of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
David H GraciasDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.

Funding

Minimally Invasive Micro-Nanoscale Tools and Devices for MedicineDP2OD004346 · OD · JOHNS HOPKINS UNIVERSITY · PI GRACIAS, DAVID H · 2008 to 2009
$2.5M
NIH HHS DP2 OD004346
6 · The paper itself

Abstract

Stent migration occurs in 10-40% of patients who undergo placement of esophageal stents, with higher migration rates seen in those treated for benign esophageal disorders. This remains a major drawback of esophageal stent therapy. In this paper, we propose a new surface modification method to increase the adhesion between self-expandable metallic stents (SEMS) and tissue while preserving their removability. Taking advantage of the well-known affinity between epoxide and amine terminated silane coupling agents with amine and carboxyl groups that are abundant in proteins and related molecules in the human body; we modified the surfaces of silicone coated esophageal SEMS with these adhesive self-assembled monolayers (SAMs). We utilized vapor phase silanization to modify the surfaces of different substrates including PDMS strips and SEMS, and measured the force required to slide these substrates on a tissue piece. Our results suggest that surface modification of esophageal SEMS via covalent attachment of protein-binding coupling agents improves adhesion to tissue and could offer a solution to reduce SEMS migration while preserving their removability.

Indexed as

coatinggastrointestinalproteinspull-forceSelf-assembled monolayer

Identifiers

PMID25663731
PMCPMC4313738

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.