ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Decreased muscle endurance associated with diabetic neuropathy may be attributed partially to neuromuscular transmission failure.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 43 citations in OpenAlex.
- Diabetic Polyneuropathy Patients Exhibit an Altered Skeletal Muscle Proteome Phenotype.Proteomics. Clinical applications · 2026Article
- Compound Muscle Action Potential Parameters of the Extensor Digitorum Brevis in Sprinters and Sedentary Individuals: A Cross-Sectional Comparison.Journal of functional morphology and kinesiology · 2026Article
- Multimodal Rehabilitative Outcome Measures of Fatigue in Patients with Diabetic Neuropathy.Brain sciences · 2026Article
- Association of muscle performance and heart rate variability in middle-aged type 2 diabetes mellitus.Journal of family medicine and primary care · 2025Article
- The impact of diabetic neuropathy on the distal versus proximal comparison of weakness in lower and upper limb muscles of patients with type 2 diabetes mellitus: a cross-sectional study.Journal of musculoskeletal & neuronal interactions · 2021Article
- Greater fatigability and motor unit discharge variability in human type 2 diabetes.Physiological reports · 2020Article
- Linear mixed-effects models for the analysis of high-density electromyography with application to diabetic peripheral neuropathy.Medical & biological engineering & computing · 2020Article
- Neural Signatures of Handgrip Fatigue in Type 1 Diabetic Men and Women.Frontiers in human neuroscience · 2020Article
- Negative impact of gestational diabetes mellitus on progress of pelvic floor muscle electromyography activity: Cohort study.PloS one · 2019Article
- Effect of photobiomodulation therapy on oxidative stress markers of gastrocnemius muscle of diabetic rats subjected to high-intensity exercise.Lasers in medical science · 2018Article
- Diabetic Neuropathy and Gait: A Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017Review
- Article
- Physiology in Medicine: neuromuscular consequences of diabetic neuropathy.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- A Novel Striated Muscle-Specific Myosin-Blocking Drug for the Study of Neuromuscular Physiology.Frontiers in cellular neuroscience · 2016Article
- Effect of Tai Chi Exercise Combined with Mental Imagery Theory in Improving Balance in a Diabetic and Elderly Population.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic polyneuropathy (DPN) can cause muscle atrophy, weakness, contractile slowing, and neuromuscular transmission instability. Our objective was to assess the response of the impaired neuromuscular system of DPN in humans when stressed with a sustained maximal voluntary contraction (MVC). Baseline MVC and evoked dorsiflexor contractile properties were assessed in DPN patients (n = 10) and controls (n = 10). Surface electromyography was used to record tibialis anterior evoked maximal compound muscle action potentials (CMAPs) and neuromuscular activity during MVCs. Participants performed a sustained isometric dorsiflexion MVC for which task termination was determined by the inability to sustain ≥60% MVC torque. The fatigue protocol was immediately followed by a maximal twitch, with additional maximal twitches and MVCs assessed at 30 s and 2 min postfatigue. DPN patients fatigued ∼21% more quickly than controls (P < 0.05) and featured less relative electromyographic activity during the first one-third of the fatigue protocol compared with controls (P < 0.05). Immediately following fatigue, maximal twitch torque was reduced similarly (∼20%) in both groups, and concurrently CMAPs were reduced (∼12%) in DPN patients, whereas they were unaffected in controls (P > 0.05). Twitch torque and CMAP amplitude recovered to baseline 30 s postfatigue. Additionally, at 30 s postfatigue, both groups had similar (∼10%) reductions in MVC torque relative to baseline, and MVC strength recovered by 2 min postfatigue. We conclude DPN patients possess less endurance than controls, and neuromuscular transmission failure may contribute to this greater fatigability.
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