ArticleGenome biology and evolution2015
Clustering of two genes putatively involved in cyanate detoxification evolved recently and independently in multiple fungal lineages.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Patterns and mechanisms of fungal genome plasticity.Current biology : CB · 2025Review
- Surprising effects of differential loss in genome evolution: the last-one-out.FEMS microbiology letters · 2025Article
- Review
- Biomimetic Carbon Sequestration and Cyanate Detoxification Using Heat-Purified Carbonic Anhydrase fromBiomimetics (Basel, Switzerland) · 2023Article
- Endophyte genomes support greater metabolic gene cluster diversity compared with non-endophytes in Trichoderma.PloS one · 2023Article
- Transcriptome analysis implicates secondary metabolite production, redox reactions, and programmed cell death during allorecognition in Cryphonectria parasitica.G3 (Bethesda, Md.) · 2021Article
- Genomic clustering within functionally related gene families inComputational and structural biotechnology journal · 2020Review
- Interaction of cyanate uptake by rice seedlings with nitrate assimilation: gene expression analysis.Environmental science and pollution research international · 2019Article
- A tale of three kingdoms: members of the Phylum Nematoda independently acquired the detoxifying enzyme cyanase through horizontal gene transfer from plants and bacteria.Parasitology · 2019Article
- Chromosome rearrangements shape the diversification of secondary metabolism in the cyclosporin producing fungus Tolypocladium inflatum.BMC genomics · 2019Article
- Cyanase-independent utilization of cyanate as a nitrogen source in ascomycete yeasts.World journal of microbiology & biotechnology · 2018Article
- The birth, evolution and death of metabolic gene clusters in fungi.Nature reviews. Microbiology · 2018Review
- Perspectives of using fungi as bioresource for bioremediation of pesticides in the environment: a critical review.Environmental science and pollution research international · 2016Review
- Dimensions of Horizontal Gene Transfer in Eukaryotic Microbial Pathogens.PLoS pathogens · 2015Article
- Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungi that have the enzymes cyanase and carbonic anhydrase show a limited capacity to detoxify cyanate, a fungicide employed by both plants and humans. Here, we describe a novel two-gene cluster that comprises duplicated cyanase and carbonic anhydrase copies, which we name the CCA gene cluster, trace its evolution across Ascomycetes, and examine the evolutionary dynamics of its spread among lineages of the Fusarium oxysporum species complex (hereafter referred to as the FOSC), a cosmopolitan clade of purportedly clonal vascular wilt plant pathogens. Phylogenetic analysis of fungal cyanase and carbonic anhydrase genes reveals that the CCA gene cluster arose independently at least twice and is now present in three lineages, namely Cochliobolus lunatus, Oidiodendron maius, and the FOSC. Genome-wide surveys within the FOSC indicate that the CCA gene cluster varies in copy number across isolates, is always located on accessory chromosomes, and is absent in FOSC's closest relatives. Phylogenetic reconstruction of the CCA gene cluster in 163 FOSC strains from a wide variety of hosts suggests a recent history of rampant transfers between isolates. We hypothesize that the independent formation of the CCA gene cluster in different fungal lineages and its spread across FOSC strains may be associated with resistance to plant-produced cyanates or to use of cyanate fungicides in agriculture.
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