ReviewBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2015
The use of hypotransferrinemic mice in studies of iron biology.
Review in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Nicotinamide Mononucleotide Combined Glucose Counteracts Iron Overload-Induced Mitochondrial Dysfunction in Mice Under Hypobaric Hypoxia.Molecular & cellular proteomics : MCP · 2026Article
- Overlaps in mammalian iron and manganese homeostasis: recent advances.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Lipid-anchored melanotransferrin mediates transferrin-independent iron uptake and ferritin storage in mammals.Cell death discovery · 2026Article
- Duodenal macrophages control dietary iron absorption via local degradation of transferrin.Blood · 2023Article
- The Aging Features of Thyrotoxicosis Mice: Malnutrition, Immunosenescence and Lipotoxicity.Frontiers in immunology · 2022Article
- Iron sequestration by transferrin 1 mediates nutritional immunity inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess.Haematologica · 2019Article
- Article
- Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis.Haematologica · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The hypotransferrinemic (hpx) mouse is a model of inherited transferrin deficiency that originated several decades ago in the BALB/cJ mouse strain. Also known as the hpx mouse, this line is almost completely devoid of transferrin, an abundant serum iron-binding protein. Two of the most prominent phenotypes of the hpx mouse are severe anemia and tissue iron overload. These phenotypes reflect the essential role of transferrin in iron delivery to bone marrow and regulation of iron homeostasis. Over the years, the hpx mouse has been utilized in studies on the role of transferrin, iron and other metals in a variety of organ systems and biological processes. This review summarizes the lessons learned from these studies and suggests possible areas of future exploration using this versatile yet complex mouse model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.