ArticleJournal of the Association for Research in Otolaryngology : JARO2015
The olivocochlear reflex strength and cochlear sensitivity are independently modulated by auditory cortex microstimulation.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset.Trends in neurosciences · 2024Review
- Relationships between the expectations based on the regularity of preceding sound sequences and the medial olivocochlear reflex.PloS one · 2024Article
- Characterization of three cholinergic inputs to the cochlear nucleus.Journal of chemical neuroanatomy · 2023Article
- The Magnitude of Contralateral Suppression of Otoacoustic Emissions Is Ear- and Age-Dependent.Journal of clinical medicine · 2023Article
- Age-Related Dichotic Listening Skills in Impaired and Non-Impaired Readers: A Comparative Study.Journal of clinical medicine · 2023Article
- Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis.Frontiers in neuroscience · 2023Article
- Expectations of the timing and intensity of a stimulus propagate to the auditory periphery through the medial olivocochlear reflex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Understanding degraded speech leads to perceptual gating of a brainstem reflex in human listeners.PLoS biology · 2021Article
- The role of the medial olivocochlear reflex in psychophysical masking and intensity resolution in humans: a review.Journal of neurophysiology · 2021Review
- Auditory attentional filter in the absence of masking noise.Attention, perception & psychophysics · 2021Article
- Cochlear activity in silent cue-target intervals shows a theta-rhythmic pattern and is correlated to attentional alpha and theta modulations.BMC biology · 2021Article
- Effects of Multisession Anodal Electrical Stimulation of the Auditory Cortex on Temporary Noise-Induced Hearing Loss in the Rat.Frontiers in neuroscience · 2021Article
- Rapid Enhancement of Subcortical Neural Responses to Sine-Wave Speech.Frontiers in neuroscience · 2021Article
- The olivocochlear reflex strength in awake chinchillas is relevant for behavioural performance during visual selective attention with auditory distractors.Scientific reports · 2020Article
- Effect of Auditory Predictability on the Human Peripheral Auditory System.Frontiers in neuroscience · 2020Article
- Lateralization of cochlear dysfunction as a specific biomarker of Parkinson's disease.Brain communications · 2020Article
- Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections.Frontiers in neural circuits · 2020Review
- Efferent Inhibition of the Cochlea.Cold Spring Harbor perspectives in medicine · 2019Review
- Article
- Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference.Frontiers in systems neuroscience · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, efferent projections to the cochlear receptor are constituted by olivocochlear (OC) fibers that originate in the superior olivary complex. Medial and lateral OC neurons make synapses with outer hair cells and with auditory nerve fibers, respectively. In addition to the OC system, there are also descending projections from the auditory cortex that are directed towards the thalamus, inferior colliculus, cochlear nucleus, and superior olivary complex. Olivocochlear function can be assessed by measuring a brainstem reflex mediated by auditory nerve fibers, cochlear nucleus neurons, and OC fibers. Although it is known that the OC reflex is activated by contralateral acoustic stimulation and produces a suppression of cochlear responses, the influence of cortical descending pathways in the OC reflex is largely unknown. Here, we used auditory cortex electrical microstimulation in chinchillas to study a possible cortical modulation of cochlear and auditory nerve responses to tones in the absence and presence of contralateral noise. We found that cortical microstimulation produces two different peripheral modulations: (i) changes in cochlear sensitivity evidenced by amplitude modulation of cochlear microphonics and auditory nerve compound action potentials and (ii) enhancement or suppression of the OC reflex strength as measured by auditory nerve responses, which depended on the intersubject variability of the OC reflex. Moreover, both corticofugal effects were not correlated, suggesting the presence of two functionally different efferent pathways. These results demonstrate that auditory cortex electrical microstimulation independently modulates the OC reflex strength and cochlear sensitivity.
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