ReviewCurrent genetics2015
An integrated view on a eukaryotic osmoregulation system.
Review in Current genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 131 citations in OpenAlex.
- Article
- Anhydrobiosis as a Model of Aging and Longevity: The Role of Autophagy and Metabolism in Yeast Cells.Microbial ecology · 2026Review
- Early lipid-mediated responses to hyperosmotic stress at the yeast vacuole.Molecular biology of the cell · 2026Article
- Hog1 plays a role in regulating lipid droplet homeostasis.Archives of microbiology · 2025Article
- The relationship mammalian p38 with human health and its homolog Hog1 in response to environmental stresses inFrontiers in cell and developmental biology · 2025Review
- Regulation of Catalase Expression and Activity byJournal of fungi (Basel, Switzerland) · 2024Article
- The cAMP-PKA signalling crosstalks with CWI and HOG-MAPK pathways in yeast cell response to osmotic and thermal stress.Microbial cell (Graz, Austria) · 2024Review
- Hyper-Production of Pullulan by a Novel Fungus ofInternational journal of molecular sciences · 2023Article
- Regulation of cell differentiation to promote pullulan synthesis in Aureobasidium pullulans NG.Applied microbiology and biotechnology · 2023Article
- Survival of Icelandic airborne microbes towards simulated atmospheric stress factors.Extremophiles : life under extreme conditions · 2023Article
- MAPkinases regulate secondary metabolism, sexual development and light dependent cellulase regulation in Trichoderma reesei.Scientific reports · 2023Article
- The regulatory mechanism of the yeast osmoresponse under different glucose concentrations.iScience · 2023Article
- Article
- Regulation of Cdc42 protein turnover modulates the filamentous growth MAPK pathway.The Journal of cell biology · 2022Article
- The role of the glycerol transporter channel Fps1p in cellular proteostasis during enhanced proteotoxic stress.Applied microbiology and biotechnology · 2022Article
- Yeast osmoregulation - glycerol still in pole position.FEMS yeast research · 2022Review
- Truth in wine yeast.Microbial biotechnology · 2022Review
- Article
- Assessment of Yeasts as Potential Probiotics: A Review of Gastrointestinal Tract Conditions and Investigation Methods.Journal of fungi (Basel, Switzerland) · 2022Review
- Dicarbonyl/L-xylulose reductase (DCXR) producing xylitol regulates egg retention through osmolality control inAnimal cells and systems · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osmoregulation encompasses active homeostatic processes that ensure proper cell volume, shape and turgor as well as an intercellular milieu optimal for the diverse biochemical processes. Recent studies demonstrate that yeast cells operate within a tight window of cellular water concentrations that still allows rapid diffusion of biomolecules while already moderate cell compression following hyper-osmotic stress leads to macromolecular crowding and a slow-down of cellular processes. Yeast cells accumulate glycerol as compatible osmolyte under hyper-osmotic stress to regain cell volume and turgor and release glycerol following a hypo-osmotic shock. The high osmolarity glycerol (HOG) response pathway controls glycerol accumulation at various levels, where each mechanism contributes to the temporal and quantitative pattern of volume recovery: inhibition of glycerol efflux, direct activation of the first enzyme in glycerol biosynthesis, stimulation of glycolytic flux as well as upregulation of expression of genes encoding enzymes in glycerol biosynthesis and an active glycerol uptake system. The HOG mitogen-activated protein kinase (MAPK) pathway communicates with the other yeast MAPK pathways to control cell morphogenesis. Cross-talk between the MAPK pathways has recently been used to re-wire osmostress-controlled expression of glycerol biosynthesis genes from Hog1 to Kss1-Fus3. The results of this study further illustrate the key importance of glycerol accumulation under osmostress and allow studying Hog1-dependent and independent processes as well as redundancy and robustness of the MAPK system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.