Evidence map›Paper›PMID 25663153›Full record

ReviewCurrent psychiatry reports2015

Management of delirium in palliative care: a review.

Luigi Grassi, Augusto Caraceni, Alex J Mitchell, Maria Giulia Nanni, Maria Alejandra Berardi, Rosangela Caruso, Michelle Riba

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current psychiatry reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Drug therapy for delirium in terminally ill adults.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Association among rescue neuroleptic use, agitation, and perceived comfort: secondary analysis of a randomized clinical trial on agitated delirium.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Trial
  4. Preventing and treating delirium in clinical settings for older adults.Therapeutic advances in psychopharmacology · 2023
    Review
  5. Article
  6. Review
  7. The prevalence, associated factors, clinical impact, and state of diagnosis of delirium in palliative care patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  8. Review
  9. Observational
  10. Article
  11. Risk Factors and Antipsychotic Usage Patterns Associated With Terminal Delirium in a Veteran Long-Term Care Hospice Population.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2021
    Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Prevalence of delirium in advanced cancer patients in home care and hospice and outcomes after 1 week of palliative care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luigi GrassiInstitute of Psychiatry, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Corso Giovecca 203, 44121, Ferrara, Italy, luigi.grassi@unife.it.
Augusto Caraceni
Alex J Mitchell
Maria Giulia Nanni
Maria Alejandra Berardi
Rosangela Caruso
Michelle Riba

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delirium is a complex but common disorder in palliative care with a prevalence between 13 and 88 % but a particular frequency at the end of life (terminal delirium). By reviewing the most relevant studies (MEDLINE, EMBASE, PsycLit, PsycInfo, Cochrane Library), a correct assessment to make the diagnosis (e.g., DSM-5, delirium assessment tools), the identification of the possible etiological factors, and the application of multicomponent and integrated interventions were reported as the correct steps to effectively manage delirium in palliative care. In terms of medications, both conventional (e.g., haloperidol) and atypical antipsychotics (e.g., olanzapine, risperidone, quetiapine, aripiprazole) were shown to be equally effective in the treatment of delirium. No recommendation was possible in palliative care regarding the use of other drugs (e.g., α-2 receptors agonists, psychostimulants, cholinesterase inhibitors, melatonergic drugs). Non-pharmacological interventions (e.g., behavioral and educational) were also shown to be important in the management of delirium. More research is necessary to clarify how to more thoroughly manage delirium in palliative care.

Indexed as

Palliative CareAntipsychotic AgentsAripiprazoleBenzodiazepinesCholinesterase InhibitorsDeliriumDisease ManagementHaloperidolHealth PersonnelHumansOlanzapineQuetiapine FumarateRisperidoneAntipsychotic AgentsAripiprazoleBenzodiazepinesCholinesterase InhibitorsHaloperidolOlanzapineQuetiapine FumarateRisperidone

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.