Evidence map›Paper›PMID 25662837›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015

An Examination of Rostral Anterior Cingulate Cortex Function and Neurochemistry in Obsessive-Compulsive Disorder.

Brian P Brennan, Olga Tkachenko, Zachary J Schwab, Richard J Juelich, Erin M Ryan, Alison J Athey, Harrison G Pope, Michael A Jenike, Justin T Baker, William D S Killgore and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Glutamate in Pediatric Obsessive-Compulsive Disorder and Response to Cognitive-Behavioral Therapy: Randomized Clinical Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Trial
  7. Article
  8. Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021
    Article
  15. Functional Brain Imaging and OCD.Current topics in behavioral neurosciences · 2021
    Review
  16. Article
  17. Article
  18. Genetics of obsessive-compulsive disorder.Indian journal of psychiatry · 2019
    Review
  19. Review
  20. Pregenual Anterior Cingulate Dysfunction Associated with Depression in OCD: An Integrated Multimodal fMRI/Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brian P Brennan1] Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA, USA [2] Obsessive-Compulsive Disorders Institute, McLean Hospital, Belmont, MA, USA [3] Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Olga TkachenkoSocial, Cognitive, and Affective Neuroscience Laboratory, McLean Hospital, Belmont, MA, USA.
Zachary J SchwabSocial, Cognitive, and Affective Neuroscience Laboratory, McLean Hospital, Belmont, MA, USA.
Richard J JuelichPsychotic Disorders Division, McLean Hospital, Belmont, MA, USA.
Erin M RyanBiological Psychiatry Laboratory, McLean Hospital, Belmont, MA, USA.
Alison J AtheyBiological Psychiatry Laboratory, McLean Hospital, Belmont, MA, USA.
Harrison G Pope1] Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA, USA [2] Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Michael A Jenike1] Obsessive-Compulsive Disorders Institute, McLean Hospital, Belmont, MA, USA [2] Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Justin T Baker1] Department of Psychiatry, Harvard Medical School, Boston, MA, USA [2] Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA.
William D S Killgore1] Department of Psychiatry, Harvard Medical School, Boston, MA, USA [2] Social, Cognitive, and Affective Neuroscience Laboratory, McLean Hospital, Belmont, MA, USA [3] Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, USA.
James I Hudson1] Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA, USA [2] Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
J Eric Jensen1] Department of Psychiatry, Harvard Medical School, Boston, MA, USA [2] McLean Imaging Center, McLean Hospital, Belmont, MA, USA.
Scott L Rauch1] Department of Psychiatry, Harvard Medical School, Boston, MA, USA [2] Social, Cognitive, and Affective Neuroscience Laboratory, McLean Hospital, Belmont, MA, USA.

Funding

Frontoparietal Network Integrity and Risk for PsychosisK23MH104515 · NIMH · MCLEAN HOSPITAL · PI BAKER, JUSTIN T · 2014 to 2018
$907k
Glutamatergic Mediators of Antidepressant Response in Major DepressionK23MH092397 · NIMH · MCLEAN HOSPITAL · PI BRENNAN, BRIAN P. · 2011 to 2015
$895k
NIMH NIH HHS K23 MH092397NIMH NIH HHS K23-MH092397NIMH NIH HHS K23 MH104515NIMH NIH HHS K23-MH104515
6 · The paper itself

Abstract

The anterior cingulate cortex is implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, few studies have examined functional and neurochemical abnormalities specifically in the rostral subdivision of the ACC (rACC) in OCD patients. We used functional magnetic resonance imaging (fMRI) during an emotional counting Stroop task and single-voxel J-resolved proton magnetic resonance spectroscopy ((1)H-MRS) in the rACC to examine the function and neurochemistry of the rACC in individuals with OCD and comparison individuals without OCD. Between-group differences in rACC activation and glutamine/glutamate ratio (Gln/Glu), Glu, and Gln levels, as well as associations between rACC activation, Gln/Glu, Glu, Gln, behavioral, and clinical measures were examined using linear regression. In a sample of 30 participants with OCD and 29 age- and sex-matched participants without OCD, participants with OCD displayed significantly reduced rACC deactivation compared with those without OCD in response to OCD-specific words versus neutral words on the emotional counting Stroop task. However, Gln/Glu, Glu, and Gln in the rACC did not differ between groups nor was there an association between reduced rACC deactivation and Gln/Glu, Glu, or Gln in the OCD group. Taken together, these findings strengthen the evidence for rACC dysfunction in OCD, but weigh against an underlying association with abnormal rACC glutamatergic neurotransmission.

Indexed as

AdolescentAdultFemaleGlutamic AcidGlutamineGyrus CinguliHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedNeuropsychological TestsObsessive-Compulsive DisorderOxygenProtonsGlutamic AcidGlutamineOxygenProtons

Identifiers

PMID25662837
PMCPMC4839510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.