ArticlePsychopharmacology2015
On the positive and negative affective responses to cocaine and their relation to drug self-administration in rats.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Examining the transdiagnostic role of coping motives and experiential avoidance in the relationship between generalized anxiety disorder and addictive behaviours.Journal of behavioral addictions · 2026Article
- Independent Heritability of Aversive Learning Influences on Cocaine-Seeking and Punishment Resistance in Rats.eNeuro · 2026Article
- Adult rat ultrasonic vocalizations and reward: Effects of propranolol and repeated cocaine administration.Journal of psychopharmacology (Oxford, England) · 2024Article
- Effects of Serial Polydrug Use on the Rewarding and Aversive Effects of the Novel Synthetic Cathinone Eutylone.Brain sciences · 2023Article
- Bright light treatment counteracts stress-induced sleep alterations in mice, via a visual circuit related to the rostromedial tegmental nucleus.PLoS biology · 2023Article
- Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats.Cell reports · 2023Article
- Male and female C57BL/6 mice display drug-induced aversion and reward in the combined conditioned taste avoidance/conditioned place preference procedure.Pharmacology, biochemistry, and behavior · 2023Article
- Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability.Pharmacology, biochemistry, and behavior · 2022Article
- Impact of the Aversive Effects of Drugs on Their Use and Abuse.Behavioural neurology · 2022Review
- Synaptic Adaptations at the Rostromedial Tegmental Nucleus Underlie Individual Differences in Cocaine Avoidance Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Distinct relationships between risky decision making and cocaine self-administration under short- and long-access conditions.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- Abuse potential and toxicity of the synthetic cathinones (i.e., "Bath salts").Neuroscience and biobehavioral reviews · 2020Review
- Methamphetamine self-administration in a runway model of drug-seeking behavior in male rats.Pharmacology, biochemistry, and behavior · 2018Article
- Modeling the development of drug addiction in male and female animals.Pharmacology, biochemistry, and behavior · 2018Review
- Antagonism of the kappa opioid receptor attenuates THC-induced place aversions in adult male Sprague-Dawley rats.Pharmacology, biochemistry, and behavior · 2017Article
- The Affective Properties of Synthetic Cathinones: Role of Reward and Aversion in Their Abuse.Current topics in behavioral neurosciences · 2017Review
- Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability.Drug and alcohol dependence · 2016Article
- Pharmacological modulation of lateral habenular dopamine D2 receptors alters the anxiogenic response to cocaine in a runway model of drug self-administration.Behavioural brain research · 2016Article
- Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood.British journal of pharmacology · 2016Article
- CRF antagonism within the ventral tegmental area but not the extended amygdala attenuates the anxiogenic effects of cocaine in rats.Pharmacology, biochemistry, and behavior · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleAcute cocaine administration produces an initial rewarding state followed by a dysphoric/anxiogenic "crash."
objectiveThe objective of this study was to determine whether individual differences in the relative value of cocaine's positive and negative effects would account for variations in subsequent drug self-administration.
methodsThe dual actions of cocaine were assessed using a conditioned place test (where animals formed preferences for environments paired with the immediate rewarding effects of 1.0mg/kg i.v. cocaine or aversions of environments associated with the anxiogenic effects present 15-min postinjection) and a runway test (where animals developed approach-avoidance "retreat" behaviors about entering a goal box associated with cocaine delivery). Ranked scores from these two tests were then correlated with each other and with the escalation in the operant responding of the same subjects observed over 10 days of 1- or 6-h/day access to i.v. (0.4 mg/inj) cocaine self-administration.
resultsLarger place preferences were associated with faster runway start latencies (r s = -0.64), but not with retreat frequency or run times; larger place aversions predicted slower runway start times (r s = 0.62), increased run times (r s = 0.65), and increased retreats (r s = 0.62); response escalation was observed in both the 1- and 6-h self-administration groups and was associated with increased CPPs (r s = 0.58) but not CPAs, as well as with faster run times (r s = -0.60).
conclusionsTogether, these data suggest that animals exhibiting a greater positive than negative response to acute (single daily injections of) cocaine are at the greatest risk for subsequent escalated cocaine self-administration, a presumed indicator of cocaine addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.