ArticleInternational orthopaedics2015
Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation.
Article in International orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04883892 (BMAC vs HA in Infiltrative Therapy for Osteoarthritis of the Ankle), which is not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BMAC vs HA in Infiltrative Therapy for Osteoarthritis of the Ankle: Randomized Controlled Clinical Trial
Who cites it
34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Clinical Applicability of Autologous Chondrocyte Implantation for the Treatment of Osteochondral Defects: A Meta-analysis.Current rheumatology reviews · 2024Pooled it
- Limited evidence in support of bone marrow aspirate concentrate as an additive to the bone marrow stimulation for osteochondral lesions of the talus: a systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Prognostic factors for the management of chondral defects of the knee and ankle joint: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Pooled it
- Cell therapies for chondral defects of the talus: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- The comparison between the different generations of autologous chondrocyte implantation with other treatment modalities: a systematic review of clinical trials.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Pooled it
- Stem cells in articular cartilage regeneration.Journal of orthopaedic surgery and research · 2016Pooled it
- Topical co-delivery of platelet rich fibrin and tranexamic acid does not decrease blood loss in primary total knee arthroplasty compared to the standard of care: a prospective, randomized, controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Trial
- Applications of bone regenerative medicine in the foot and ankle: mechanisms, technologies, and therapeutic advances.Frontiers in bioengineering and biotechnology · 2025Review
- Fibrin glue does not promote migration and proliferation of bone marrow derived mesenchymal stem cells in collagenic membranes: an in vitro study.Scientific reports · 2022Article
- Fibrin glue does not assist migration and proliferation of chondrocytes in collagenic membranes: an in vitro study.Journal of orthopaedic surgery and research · 2022Article
- Demographics in Patients Receiving Matrix-Assisted Chondrocyte Implantation (MACI) in the Ankle.Cartilage · 2021Article
- Osteochondral Lesions of the Talus: A Review on Talus Osteochondral Injuries, Including Osteochondritis Dissecans.Cartilage · 2021Review
- Combined Bone Marrow Aspirate and Platelet-Rich Plasma for Cartilage Repair: Two-Year Clinical Results.Cartilage · 2021Article
- High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects.Cartilage · 2021Article
- A Novel Medial Malleolar Osteotomy Technique for the Treatment of Osteochondral Lesions of the Talus.Orthopaedic journal of sports medicine · 2021Article
- Does the Application of Platelet-Rich Fibrin in Anterior Cruciate Ligament Reconstruction Enhance Graft Healing and Maturation? A Comparative MRI Study of 44 Cases.Orthopaedic journal of sports medicine · 2020Article
- Matrix-associated stem cell transplantation is successful in treating talar osteochondral lesions.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Regenerative treatment of osteochondral lesions of distal tibial plafond.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018Article
- [Therapeutic utilization of stem cells in orthopedics].Der Orthopade · 2017Article
- Scaffolds based therapy for osteochondral lesions of the talus: A systematic review.World journal of orthopedics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOsteochondral lesions of the talus (OLT) usually require surgical treatment. Regenerative techniques for hyaline cartilage restoration, like autologous chondrocytes implantation (ACI) or bone marrow derived cells transplantation (BMDCT), should be preferred. The aim of this work is comparing two clusters with OLT, treated with ACI or BMDCT.
methodsEighty patients were treated with regenerative techniques, 40 with ACI and 40 with BMDCT. The two groups were homogenous regarding age, lesion size and depth, previous surgeries, etiology of the lesion, subchondral bone graft, final follow-up and pre-operative AOFAS score. The two procedures were performed arthroscopically. The scaffold was a hyaluronic acid membrane in all the cases, loaded with previously cultured chondrocytes (ACI) or with bone marrow concentrated cells, harvested in the same surgical session (BMDCT). All the patients were clinically and radiologically evaluated, using MRI Mocart score and T2 mapping sequence.
resultsClinical results were similar in both groups at 48 months. No statistically significant influence was reported after evaluation of all the pre-operative parameters. The rate of return to sport activity showed slightly better results for BMDCT than ACI. MRI Mocart score was similar in both groups. MRI T2 mapping evaluation highlighted a higher presence of hyaline like values in the BMDCT group, and lower incidence of fibrocartilage as well.
conclusionsTo date, ACI and BMDCT showed to be effective regenerative techniques for the treatment of OLT. BMDCT could be preferred over ACI for the single step procedure, patients' discomfort and lower costs.
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Registered trials
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