ArticleMedicina oral, patologia oral y cirugia bucal2015
Anti-inflammatory effects of zinc in PMA-treated human gingival fibroblast cells.
Article in Medicina oral, patologia oral y cirugia bucal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Evaluation of zinc sulfate mucoadhesive formulation on recurrent aphthous stomatitis: a randomized double-blind, placebo-controlled clinical trial.BMC oral health · 2020Trial
- Review
- Zinc supplementation for postoperative sore throat prevention: evidence from a systematic review and meta-analysis.Journal of dental anesthesia and pain medicine · 2025Review
- Molecular pathogenicity of 1-nonadecene and L-lactic acid, unique metabolites in radicular cysts and periapical granulomas.Scientific reports · 2023Article
- Immunomodulatory effects of chicken cathelicidin-2 on a primary hepatic cell co-culture model.PloS one · 2022Article
- Oral wound healing models and emerging regenerative therapies.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Article
- Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy.Medicina oral, patologia oral y cirugia bucal · 2020Article
- Conditional nutrition (I): concerning zinc as a beneficial but variable regulator of inflammation and experimental arthritis.Inflammopharmacology · 2020Article
- Preoperative oral zinc tablet decreases incidence of postoperative sore throat.Indian journal of anaesthesia · 2020Article
- Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS).BMC oral health · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAbnormal cellular immune response has been considered to be responsible for oral lesions in recurrent aphthous stomatitis. Zinc has been known to be an essential nutrient metal that is necessary for a broad range of biological activities including antioxidant, immune mediator, and anti-inflammatory drugs in oral mucosal disease. The objective of this study was to investigate the effects of zinc in a phorbol-12-myristate-13-acetate (PMA)-treated inflammatory model on human gingival fibroblast cells (hGFs). STUDY
designCells were pre-treated with zinc chloride, followed by PMA in hGFs. The effects were assessed on cell viability, cyclooxygenease-1,2(COX-1,2) protein expression, PGE2 release, ROS production and cytokine release, Results: The effects were assessed on cell viability, COX1/2 protein expression, PGE2 release, ROS production, cytokine release. The results showed that, in the presence of PMA, zinc treatment leads to reduce the production of ROS, which results in decrease of COX-2 expression and PGE2 release.
conclusionsThus, we suggest that zinc treatment leads to the mitigation of oral inflammation and may prove to be an alternative treatment for recurrent aphthous stomatitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.