Evidence map›Paper›PMID 25662455›Full record

ArticleMethods in enzymology2015

Methods to study molecular mechanisms of the Neurospora circadian clock.

Joonseok Cha, Mian Zhou, Yi Liu

Abstract read
In one paragraph

Article in Methods in enzymology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. IMITATION SWITCH is required for normal chromatin structure and gene repression in PRC2 target domains.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joonseok ChaDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mian ZhouDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yi LiuDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: yi.liu@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

Transcriptional and Posttranscriptional Regulation of Neurospora Circadian ClockR01GM068496 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LIU, YI · 2003 to 2015
$4.5M
MOLECULAR MECHANISMS OF THE NEUROSPORA CIRCADIAN CLOCKR01GM062591 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LIU, YI · 2001 to 2013
$3.8M
Mechanism and functions of small RNA pathways in NeurosporaR01GM084283 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LIU, YI · 2009 to 2015
$2.1M
NIGMS NIH HHS R01 GM062591NIGMS NIH HHS R01 GM068496NIGMS NIH HHS R01 GM084283
6 · The paper itself

Abstract

Eukaryotic circadian clocks are comprised of interlocked autoregulatory feedback loops that control gene expression at the levels of transcription and translation. The filamentous fungus Neurospora crassa is an excellent model for the complex molecular network of regulatory mechanisms that are common to all eukaryotes. At the heart of the network, posttranslational regulation and functions of the core clock elements are of major interest. This chapter discusses the methods used currently to study the regulation of clock molecules in Neurospora. The methods range from assays of gene expression to phosphorylation, nuclear localization, and DNA binding of clock proteins.

Indexed as

Circadian ClocksCLOCK ProteinsFungal ProteinsGene Expression Regulation, FungalNeurospora crassaPhosphorylationProtein Processing, Post-TranslationalCLOCK ProteinsFungal ProteinsCircadian clockFREQUENCYKinaseNeurosporaPhosphorylationWHITE COLLAR-1

Identifiers

PMID25662455
PMCPMC4617788
OpenAlexW2340768967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.