ArticleCancer epidemiology2015
The incidence of oesophageal cancer in Eastern Africa: identification of a new geographic hot spot?
Article in Cancer epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Systematic review and meta-analysis of esophageal cancer in Africa: Epidemiology, risk factors, management and outcomes.World journal of gastroenterology · 2019Pooled it
- Is Clinical Research in Oesophageal Cancer in South Africa in Crisis? A Systematic Review.World journal of surgery · 2017Pooled it
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- Treatment Response in Advanced and Metastatic Esophageal Cancer Patients on Palliative Treatments in Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia: A Retrospective Study.Research square · 2026Article
- The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.Ecancermedicalscience · 2026Review
- Esophageal cancer staging in Malawi: the feasibility of chest radiography and abdominal ultrasound for initial evaluation.BMC gastroenterology · 2025Observational
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- A plea for urgent action: Addressing the critical shortage of cardiothoracic surgical workforce in the COSECSA region.World journal of surgery · 2024Article
- Rural-urban disparity in cancer burden and care: findings from an Indian cancer registry.BMC cancer · 2024Article
- The distribution of esophageal cancer patients enrolled in care at the Uganda Cancer Institute by sub-regions, districts and ethnicity.African health sciences · 2024Article
- Landscape of esophageal cancer in Northern Kenya: experience from Garissa Regional Cancer Center.Ecancermedicalscience · 2024Article
- The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities.Gut microbes · 2023Review
- A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Clinicopathological characteristics and treatment outcomes of oesophageal cancer patients in Uganda.Ecancermedicalscience · 2023Article
- An international report on bacterial communities in esophageal squamous cell carcinoma.International journal of cancer · 2022Article
- Risk Factors Associated With Early-Onset Esophageal Cancer in Tanzania.JCO global oncology · 2022Article
- Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study.BMC cancer · 2022Article
- Tobacco and other risk factors for esophageal squamous cell carcinoma in Lilongwe Malawi: Results from the Lilongwe esophageal cancer case: Control study.PLOS global public health · 2022Article
- Demographic, endoscopic and histological profile of esophageal cancer at the Gastroenterology Department of Maputo Central Hospital from January 2016 to December 2018.The Pan African medical journal · 2022Article
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Authors and funding
10 authors at 6 institutions in 5 countries.
Funding
Abstract
The incidence of oesophageal cancer (OC) varies geographically, with more than 80% of cases and deaths worldwide occurring in developing countries. The aim of this study is to characterize the disease burden of OC in four urban populations in Eastern Africa, which may represent a previously undescribed high-incidence area. Data on all cases of OC diagnosed between 2004 and 2008 were obtained from four population-based cancer registries in: Blantyre, Malawi; Harare, Zimbabwe; Kampala, Uganda; and Nairobi, Kenya. Age-standardized incidence rates (ASRs) were calculated for each population, and descriptive statistics for incident cases were determined. In Blantyre, 351 male (59%) and 239 (41%) female cases were reported, with ASRs of 47.2 and 30.3. In Harare, 213 male (61%) and 134 (39%) female cases were reported, with ASRs of 33.4 and 25.3, respectively. In Kampala, 196 male (59%) and 137 female (41%) cases were reported, with ASRs of 36.7 and 24.8. In Nairobi, 323 male (57%) and 239 female (43%) cases were reported, with ASRs of 22.6 and 21.6. Median age at diagnosis was significantly different among the four populations, ranging from 50 years in Blantyre to 65 years in Harare (p<0.0001). Except in Nairobi, incidence among males was significantly higher than among females (p<0.01). Squamous cell OC was the predominant histologic subtype at all sites. ASRs at all four sites were remarkably higher than the mean worldwide ASR. Investigation to evaluate potential etiologic effects of dietary, lifestyle, environmental, and other factors impacting the incidence in this region is needed.
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