ArticleVirology2015
Impact of route of exposure and challenge dose on the pathogenesis of H7N9 low pathogenicity avian influenza virus in chickens.
Article in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Genetic resilience or resistance in poultry against avian influenza virus: mirage or reality?Journal of virology · 2025Review
- Coinfection of Chickens with H9N2 and H7N9 Avian Influenza Viruses Leads to Emergence of Reassortant H9N9 Virus with Increased Fitness for Poultry and a Zoonotic Potential.Journal of virology · 2022Article
- A Stochastic SEIRS Epidemic Model with Infection Forces and Intervention Strategies.Journal of healthcare engineering · 2022Article
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- Optimizing the early detection of low pathogenic avian influenza H7N9 virus in live bird markets.Journal of the Royal Society, Interface · 2021Article
- Neuraminidase-associated plasminogen recruitment enables systemic spread of natural avian Influenza viruses H3N1.PLoS pathogens · 2021Article
- Mutations in PB1, NP, HA, and NA Contribute to Increased Virus Fitness of H5N2 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4 in Chickens.Journal of virology · 2021Article
- Exploring utility of genomic epidemiology to trace origins of highly pathogenic influenza A/H7N9 in Guangdong.Virus evolution · 2020Article
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- Article
- Loss of Fitness of Mexican H7N3 Highly Pathogenic Avian Influenza Virus in Mallards after Circulating in Chickens.Journal of virology · 2019Article
- Virulence of three European highly pathogenic H7N1 and H7N7 avian influenza viruses in Pekin and Muscovy ducks.BMC veterinary research · 2019Article
- One health insights to prevent the next HxNy viral outbreak: learning from the epidemiology of H7N9.BMC infectious diseases · 2019Article
- Assessment of low pathogenic avian influenza virus transmission via raw poultry meat and raw table eggs.EFSA journal. European Food Safety Authority · 2018Article
- Unexpected infection outcomes of China-origin H7N9 low pathogenicity avian influenza virus in turkeys.Scientific reports · 2018Article
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- Artificial infectious disease optimization: A SEIQR epidemic dynamic model-based function optimization algorithm.Swarm and evolutionary computation · 2016Article
- Transmission of H7N9 Influenza Viruses with a Polymorphism at PB2 Residue 627 in Chickens and Ferrets.Journal of virology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
H7N9 influenza A first caused human infections in early 2013 in China. Virus genetics, histories of patient exposures to poultry, and previous experimental studies suggest the source of the virus is a domestic avian species, such as chickens. In order to better understand the ecology of this H7N9 in chickens, we evaluated the infectious dose and pathogenesis of A/Anhui/1/2013 H7N9 in two common breeds of chickens, White Leghorns (table-egg layers) and White Plymouth Rocks (meat chickens). No morbidity or mortality were observed with doses of 10(6) or 10(8)EID50/bird when administered by the upper-respiratory route, and the mean infectious dose (10(6) EID50) was higher than expected, suggesting that the virus is poorly adapted to chickens. Virus was shed at higher titers and spread to the kidneys in chickens inoculated by the intravenous route. Challenge experiments with three other human-origin H7N9 viruses showed a similar pattern of virus replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.