Evidence map›Paper›PMID 25662269›Full record

ReviewCurrent topics in developmental biology2015

The role of foxi family transcription factors in the development of the ear and jaw.

Renée K Edlund, Onur Birol, Andrew K Groves

Abstract readReview
In one paragraph

Review in Current topics in developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Foxi3Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Uncovering the secreted signals and transcription factors regulating the development of mammalian middle ear ossicles.Developmental dynamics : an official publication of the American Association of Anatomists · 2020
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The quest for restoring hearing: Understanding ear development more completely.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Renée K EdlundProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.
Onur BirolProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA.
Andrew K GrovesProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA; Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA. Electronic address: akgroves@bcm.edu.

Funding

Genetic Regulation of Inner, Middle and Outer Ear DevelopmentR01DC013072 · NIDCD · WASHINGTON UNIVERSITY · PI GROVES, ANDREW K · 2013 to 2025
$5.1M
NIDCD NIH HHS R01 DC013072
6 · The paper itself

Abstract

The mammalian outer, middle, and inner ears have different embryonic origins and evolved at different times in the vertebrate lineage. The outer ear is derived from first and second branchial arch ectoderm and mesoderm, the middle ear ossicles are derived from neural crest mesenchymal cells that invade the first and second branchial arches, whereas the inner ear and its associated vestibule-acoustic (VIIIth) ganglion are derived from the otic placode. In this chapter, we discuss recent findings in the development of these structures and describe the contributions of members of a Forkhead transcription factor family, the Foxi family to their formation. Foxi transcription factors are critical for formation of the otic placode, survival of the branchial arch neural crest, and developmental remodeling of the branchial arch ectoderm.

Indexed as

AnimalsBiological EvolutionBranchial RegionEarEctodermForkhead Transcription FactorsJawMammalsMorphogenesisNeural CrestForkhead Transcription FactorsBranchial archesCraniofacialForkheadNeural crestPharyngeal archesPlacodeSensory organTranscription factors

Identifiers

PMID25662269
PMCPMC4593480

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.