Evidence map›Paper›PMID 25662068›Full record

ArticleBiostatistics (Oxford, England)2015

Combining parametric, semi-parametric, and non-parametric survival models with stacked survival models.

Andrew Wey, John Connett, Kyle Rudser

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Biostatistics (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Machine learning versus regression for prediction of sporadic pancreatic cancer.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023
    Article
  5. Review
  6. Article
  7. Stacked survival models for residual lifetime data.BMC medical research methodology · 2022
    Article
  8. The relationship between the C-statistic and the accuracy of program-specific evaluations.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrew WeyUniversity of Hawaii, Honolulu, HI 96815, USAUniversity of Minnesota, Minneapolis, MN 55455, USA awey@hawaii.edu.
John ConnettUniversity of Hawaii, Honolulu, HI 96815, USAUniversity of Minnesota, Minneapolis, MN 55455, USA.
Kyle RudserUniversity of Hawaii, Honolulu, HI 96815, USAUniversity of Minnesota, Minneapolis, MN 55455, USA.
University of Hawaii System · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI HEDGES, JERRIS ROBERT, MOKUAU, NOREEN · 2012 to 2018
$21.1M
RESEARCH DESIGN, BIOSTATISTICS AND RESEARCH ETHICS COREG12MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 2012 to 2016
$13.0M
NCATS NIH HHS UL1TR000114NCATS NIH HHS UL1 TR002494NIMHD NIH HHS G12MD007601NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54MD007584
6 · The paper itself

Abstract

For estimating conditional survival functions, non-parametric estimators can be preferred to parametric and semi-parametric estimators due to relaxed assumptions that enable robust estimation. Yet, even when misspecified, parametric and semi-parametric estimators can possess better operating characteristics in small sample sizes due to smaller variance than non-parametric estimators. Fundamentally, this is a bias-variance trade-off situation in that the sample size is not large enough to take advantage of the low bias of non-parametric estimation. Stacked survival models estimate an optimally weighted combination of models that can span parametric, semi-parametric, and non-parametric models by minimizing prediction error. An extensive simulation study demonstrates that stacked survival models consistently perform well across a wide range of scenarios by adaptively balancing the strengths and weaknesses of individual candidate survival models. In addition, stacked survival models perform as well as or better than the model selected through cross-validation. Finally, stacked survival models are applied to a well-known German breast cancer study.

Indexed as

Models, StatisticalSurvival AnalysisBiasBiostatisticsBreast NeoplasmsComputer SimulationDatabases, FactualFemaleGermanyHumansLinear ModelsNonlinear DynamicsStatistics, NonparametricBias–variance trade-offBrier scoreCross-validationStacked regressionsSurvival ensemblesSurvival prediction

Identifiers

PMID25662068
PMCPMC5963472
OpenAlexW2043546065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.