Trial reportAddictive behaviors2015
Cognitive performance in a placebo-controlled pharmacotherapy trial for youth with marijuana dependence.
Trial report in Addictive behaviors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Pharmacotherapies for cannabis use disorder.The Cochrane database of systematic reviews · 2025Pooled it
- Pharmacotherapies for cannabis dependence.The Cochrane database of systematic reviews · 2019Pooled it
- Weighing the Evidence: A Systematic Review on Long-Term Neurocognitive Effects of Cannabis Use in Abstinent Adolescents and Adults.Neuropsychology review · 2016Pooled it
- Effect of four-week cannabidiol treatment on cognitive function: secondary outcomes from a randomised clinical trial for the treatment of cannabis use disorder.Psychopharmacology · 2023Trial
- One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory.The Journal of clinical psychiatry · 2018Trial
- Cognitive Effects of Cannabis Use: A Comprehensive Review Across Domains.Neurology international · 2025Review
- Neurocognitive outcomes in adolescents with and without four weeks of cannabis abstinence: a randomized clinical trial using contingency management.Frontiers in psychiatry · 2025Article
- Regular recreational Cannabis users exhibit altered neural oscillatory dynamics during attention reorientation.Psychological medicine · 2023Article
- Bridges to Sobriety: Testing the Feasibility and Acceptability of a Mobile App Designed to Supplement an Adolescent Substance Use Disorder Treatment Program.Clinical social work journal · 2022Article
- Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife.The American journal of psychiatry · 2022Article
- Investigating the Residual Effects of Chronic Cannabis Use and Abstinence on Verbal and Visuospatial Learning.Frontiers in psychiatry · 2021Article
- Impact of 2 Weeks of Monitored Abstinence on Cognition in Adolescent and Young Adult Cannabis Users.Journal of the International Neuropsychological Society : JINS · 2020Article
- Cognitive Functioning Related to Binge Alcohol and Cannabis Co-Use in Abstinent Adolescents and Young Adults.Journal of studies on alcohol and drugs · 2020Article
- Associations of Parental Marijuana Use With Offspring Marijuana, Tobacco, and Alcohol Use and Opioid Misuse.JAMA network open · 2019Article
- Use of N-Acetylcysteine in Psychiatric Conditions among Children and Adolescents: A Scoping Review.Cureus · 2017Article
- Alcohol and Drug Use and the Developing Brain.Current psychiatry reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAdolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance.
methodsThis secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery.
resultsAbstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores.
conclusionsThese findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.