Evidence map›Paper›PMID 25661804›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2015

Fulminant endocarditis and disseminated infection caused by carbapenem-resistant Acinetobacter baumannii in a renal-pancreas transplant recipient.

G Patel, F Perez, A M Hujer, S D Rudin, J J Augustine, G H Jacobs, M R Jacobs, R A Bonomo

Open access · greenAbstract readCase Reports
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Prosthetic Valve Endocarditis byPathogens (Basel, Switzerland) · 2026
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Carbapenemases: TransformingBiomolecules · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

G PatelDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
F Perez
A M Hujer
S D Rudin
J J Augustine
G H Jacobs
M R Jacobs
R A Bonomo
Louis Stokes Cleveland VA Medical Center · USCase Western Reserve University · USIcahn School of Medicine at Mount Sinai · USUniversity Hospitals Case Medical Center · USUniversity School · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
BLRD VA I01 BX001974NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1TR000439NIAID NIH HHS R01 AI063517NIAID NIH HHS R01 AI072219
6 · The paper itself

Abstract

Acinetobacter baumannii is an important cause of healthcare-associated infections, and is particularly problematic among patients who undergo organ transplantation. We describe a case of fulminant sepsis caused by carbapenem-resistant A. baumannii harboring the blaOXA-23 carbapenemase gene and belonging to international clone II. This isolate led to the death of a patient 6 days after simultaneous kidney-pancreas transplantation. Autopsy findings revealed acute mitral valve endocarditis, myocarditis, splenic and renal emboli, peritonitis, and pneumonia. This case highlights the severe nature of certain A. baumannii infections and the vulnerability of transplanted patients to the increasingly intractable "high-risk" clones of multidrug-resistant organisms.

Indexed as

Acinetobacter InfectionsEndocarditis, BacterialKidney TransplantationPancreas TransplantationPostoperative ComplicationsAcinetobacter baumanniiBacteremiaBacterial Proteinsbeta-LactamasesCarbapenemsDiabetes Mellitus, Type 1Drug Resistance, BacterialHumansKidney Failure, ChronicMaleMiddle AgedBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsAcinetobacter baumanniicarbapenem resistanceendocarditissimultaneous kidney-pancreas transplantation

Identifiers

PMID25661804
PMCPMC4380574
OpenAlexW2077470572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.