ArticlePathobiology of aging & age related diseases2015
Zinc, aging, and immunosenescence: an overview.
Article in Pathobiology of aging & age related diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 94 citations in OpenAlex.
- Ward-Level Variation and Clinical Correlates of Low Serum Zinc Among Long-Term Care Facility Residents: A Five-Year Retrospective Cohort Study.Geriatrics & gerontology international · 2026Article
- Trace elements in relation to glycemic control and disease complications in children living with type 1 diabetes mellitus.Journal of clinical biochemistry and nutrition · 2026Article
- Persistent Zinc Deficiency Among Residents of a Long-Term Care Facility: A Five-Year Longitudinal Study.Cureus · 2026Article
- Zinc: a metallic shield against cardiac inflammation.Metallomics : integrated biometal science · 2026Review
- Liraglutide Modulates Zinc Release and Improves Mitochondrial Function in Insulin-Resistant Senescent Cardiomyocytes.Cardiovascular toxicology · 2026Article
- Oral Toxicity Profile of a Novel Silk Lutein Extract and Assessment of Its Cardiovascular Benefits in Rodents.International journal of molecular sciences · 2026Article
- New insights into the role of metallothioneins in obesity and diabetes.International journal of obesity (2005) · 2025Review
- Understanding and improving vaccine efficacy in older adults.Nature aging · 2025Review
- Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle.Frontiers in immunology · 2025Review
- Impact of zinc on immunometabolism and its putative role on respiratory diseases.Immunometabolism (Cobham, Surrey) · 2025Review
- Metallothionein-1A (MT1A) Gene Variability May Play a Role in Female Frailty: A Preliminary Study.Genes · 2024Article
- Alterations in zinc, copper, and iron levels in the retina and brain of Alzheimer's disease patients and the APP/PS1 mouse model.Metallomics : integrated biometal science · 2024Article
- Dietary profiling of physical frailty in older age phenotypes using a machine learning approach: the Salus in Apulia Study.European journal of nutrition · 2023Article
- Multifunctional role of zinc in human health: an update.EXCLI journal · 2023Review
- Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components.Biogerontology · 2022Review
- Natural Compounds and Products from an Anti-Aging Perspective.Molecules (Basel, Switzerland) · 2022Review
- Fine-grained investigation of the relationship between human nutrition and global DNA methylation patterns.European journal of nutrition · 2022Article
- Review
- A Comprehensive Review of Computation-Based Metal-Binding Prediction Approaches at the Residue Level.BioMed research international · 2022Review
- Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study.International immunopharmacology · 2021Observational
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc plays an essential role in many biochemical pathways and participates in several cell functions, including the immune response. This review describes the role of zinc in human health, aging, and immunosenescence. Zinc deficiency is frequent in the elderly and leads to changes similar to those that occur in oxidative inflammatory aging (oxi-inflamm-aging) and immunosenescence. The possible benefits of zinc supplementation to enhance immune function are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.