Evidence map›Paper›PMID 25661398›Full record

ArticleJournal of affective disorders2015

Rapid cycling as a feature of bipolar disorder and comorbid migraine.

K Gordon-Smith, L Forty, C Chan, S Knott, I Jones, N Craddock, L A Jones

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

K Gordon-SmithInstitute of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK; Department of Psychiatry, School of Clinical and Experimental Medicine, University of Birmingham, UK; Bipolar Disorder Research Network (BDRN, bdrn.org), UK.
L FortyInstitute of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK; Bipolar Disorder Research Network (BDRN, bdrn.org), UK.
C ChanDepartment of Psychiatry, School of Clinical and Experimental Medicine, University of Birmingham, UK.
S KnottInstitute of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK; Bipolar Disorder Research Network (BDRN, bdrn.org), UK.
I JonesInstitute of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK; Bipolar Disorder Research Network (BDRN, bdrn.org), UK.
N CraddockInstitute of Psychological Medicine & Clinical Neurosciences, Cardiff University, UK; Bipolar Disorder Research Network (BDRN, bdrn.org), UK.
L A JonesDepartment of Psychiatry, School of Clinical and Experimental Medicine, University of Birmingham, UK; Bipolar Disorder Research Network (BDRN, bdrn.org), UK. Electronic address: l.a.jones@bham.ac.uk.
Cardiff University · GBUniversity of Birmingham · GBNIHR Clinical Research Network · GB

Funding

Medical Research Council MR/L010305/1Wellcome Trust
6 · The paper itself

Abstract

backgroundPrevious research has suggested the clinical profile of individuals with bipolar disorder (BD) differs according to the presence or absence of comorbid migraine. We aimed to determine the clinical characteristics that differentiate individuals with BD with and without comorbid migraine in a large, representative, clinically well-characterised UK sample.

methodsThe lifetime clinical characteristics of 1488 individuals with BD (BPI n=1120, BPII n=368) with and without comorbid migraine were compared (n=375 vs. n=1113 respectively).

resultsIndividuals with BD and comorbid migraine had a distinctive set of lifetime clinical characteristics. A multivariate model showed that consistent with previous studies those with comorbid migraine were significantly more likely to be female (OR=2.099, p=0.005) and have comorbid panic attacks (OR=1.842, p=0.004). A novel finding was that even after controlling for other differences, the individuals with BD and comorbid migraine were more likely to have a rapid cycling illness course (OR=1.888, p=0.002). LIMITATIONS: Presence of migraine was assessed using self report measures. Cross-sectional study design limits investigations of bidirectional associations between migraine and bipolar disorder.

conclusionsComorbid migraine in BD may represent a more homogenous subtype of BD with an unstable rapid cycling course. Identifying individuals with BD and comorbid migraine may be of use in a clinical setting and this subgroup could be the focus of future aetiological studies.

Indexed as

AdolescentBipolar DisorderComorbidityConfounding Factors, EpidemiologicCross-Sectional StudiesFemaleHumansMiddle AgedMigraine DisordersOdds RatioPanic DisorderSelf ReportSurveys and QuestionnairesUnited KingdomBipolar disorderComorbidityMigraineRapid cycling

Identifiers

PMID25661398
PMCPMC4366040
OpenAlexW2093669734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.