Evidence map›Paper›PMID 25661088›Full record

ReviewClinica chimica acta; international journal of clinical chemistry2015

Genetic determinants of risk and progression in multiple sclerosis.

Alessandro Didonna, Jorge R Oksenberg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinica chimica acta; international journal of clinical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. The genetic effect of theBioscience reports · 2018
    Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Caring for Women with Multiple Sclerosis Across the Lifespan.Current neurology and neuroscience reports · 2018
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alessandro DidonnaDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Jorge R OksenbergDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA. Electronic address: jorge.oksenberg@ucsf.edu.
University of California, San Francisco · US

Funding

Immunogenetic Studies in Multiple SclerosisR01NS046297 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OKSENBERG, JORGE R. · 2003 to 2013
$3.5M
NINDS NIH HHS R01 NS046297
6 · The paper itself

Abstract

Multiple sclerosis (MS) is an autoimmune disease that represents a primary cause of neurological disability in the young adult population. Converging evidence supports the importance of genetic determinants for MS etiology. However, with the exception of the major histocompatibility complex, their nature has been elusive for more than 20 years. In the last decade, the advent of large genome-wide association studies has significantly improved our understanding of the disease, leading to the golden era of MS genetic research. To date more than 110 genetic variants have been firmly associated to an increased risk of developing MS. A large part of these variants tag genes involved in the regulation of immune response and several of them are shared with other autoimmune diseases, suggesting a common etiological root for this class of disorders. Despite the impressive body of data obtained in the last years, we are still far from fully decoding MS genetic complexity. For example, we ignore how these genetic factors interact with each other and with the environment. Thus, the biggest challenge for the next era of MS research will consist in identifying and characterizing the molecular mechanisms and the cellular pathways in which these risk variants play a role.

Indexed as

Disease ProgressionEpigenesis, GeneticGenetic Predisposition to DiseaseGenetic VariationHumansMajor Histocompatibility ComplexMultiple SclerosisComplex diseaseGWASMultiple sclerosisRisk variant

Identifiers

PMID25661088
PMCPMC4524789
OpenAlexW1982416586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.