Evidence map›Paper›PMID 25660721›Full record

ArticleFertility and sterility2015

Perinatal outcomes associated with assisted reproductive technology: the Massachusetts Outcomes Study of Assisted Reproductive Technologies (MOSART).

Eugene Declercq, Barbara Luke, Candice Belanoff, Howard Cabral, Hafsatou Diop, Daksha Gopal, Lan Hoang, Milton Kotelchuck, Judy E Stern, Mark D Hornstein

Open access · greenAbstract read
In one paragraph

Article in Fertility and sterility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 2 pooled it
31.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 2 syntheses or guidelines pooled it, 171 citations in OpenAlex.

  1. Pooled it
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  15. The effect of fertility treatment and socioeconomic status on neonatal and post-neonatal mortality in the United States.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  16. Article
  17. Long-Term Effects of ART on the Health of the Offspring.International journal of molecular sciences · 2023
    Review
  18. Article
  19. LetrozoleHeliyon · 2023
    Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Eugene DeclercqBoston University School of Public Health, Boston, Massachusetts. Electronic address: declercq@bu.edu.
Barbara LukeMichigan State University, East Lansing, Michigan.
Candice BelanoffBoston University School of Public Health, Boston, Massachusetts.
Howard CabralBoston University School of Public Health, Boston, Massachusetts.
Hafsatou DiopMassachusetts Department of Public Health, Boston, Massachusetts.
Daksha GopalBoston University School of Public Health, Boston, Massachusetts.
Lan HoangBoston University School of Public Health, Boston, Massachusetts.
Milton KotelchuckMass General Hospital for Children, Harvard Medical School, Boston, Massachusetts.
Judy E SternGeisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Mark D HornsteinBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Boston University · USHarvard University · USDartmouth College · USMassachusetts Department of Public Health · USMichigan State University · US

Funding

Women's Health After Assisted Reproductive Technology: A Population-Based StudyR01HD067270 · NICHD · DARTMOUTH-HITCHCOCK CLINIC · PI DIOP, HAFSATOU, STERN, JUDY E · 2011 to 2020
$7.4M
Child Health After Assisted Reproductive Technology: A Population-Based StudyR01HD064595 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DECLERCQ, EUGENE R, DIOP, HAFSATOU · 2010 to 2014
$3.1M
NICHD NIH HHS R01 HD064595NICHD NIH HHS R01HD064595NICHD NIH HHS R01 HD067270NICHD NIH HHS R01HD067270
6 · The paper itself

Abstract

objectiveTo compare on a population basis the birth outcomes of women treated with assisted reproductive technologies (ART), women with indicators of subfertility but without ART, and fertile women.

designLongitudinal cohort study.

settingNot applicable. PARTICIPANT(S): A total of 334,628 births and fetal deaths to Massachusetts mothers giving birth in a Massachusetts hospital from July 1, 2004, to December 31, 2008, subdivided into three subgroups for comparison: ART 11,271, subfertile 6,609, and fertile 316,748. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Four outcomes-preterm birth, low birth weight, small for gestational age, and perinatal death-were modeled separately for singletons and twins with the use of logistic regression for the primary comparison between ART births and those to the newly created population-based subgroup of births to women with indicators of subfertility but no ART. RESULT(S): For singletons, the risks for both preterm birth and low birth weight were higher for the ART group (adjusted odds ratios [AORs] 1.23 and 1.26, respectively) compared with the subfertile group, and risks in both the ART and the subfertile groups were higher than those among the fertile births group. For twins, the risk of perinatal death was significantly lower among ART births than fertile (AOR 0.55) or subfertile (AOR 0.15) births. CONCLUSION(S): The use of a population-based comparison group of subfertile births without ART demonstrated significantly higher rates of preterm birth and low birth weight in ART singleton births, but these differences are smaller than differences between ART and fertile births. Further refinement of the measurement of subfertile births and examination of the independent risks of subfertile births is warranted.

Indexed as

AdultFemaleHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeInfertilityLongitudinal StudiesMaleMassachusettsPregnancyPregnancy OutcomePregnancy RatePremature BirthReproductive Techniques, AssistedTreatment OutcomeAssisted reproductive technologieslow birth weightperinatal deathpreterm birthsubfertility

Identifiers

PMID25660721
PMCPMC4385441
OpenAlexW2016550398

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.