ArticleSocial psychiatry and psychiatric epidemiology2015
Impact of depression on quality-adjusted life expectancy (QALE) directly as well as indirectly through suicide.
Article in Social psychiatry and psychiatric epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The impact of schema therapy and its basic and mode treatment models for depressive disorders: a systematic review.BMC psychology · 2026Pooled it
- Applications of machine learning in deep brain stimulation for major depressive disorder: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.Translational psychiatry · 2025Pooled it
- Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.Nature communications · 2017Pooled it
- Interpretable depressive symptoms screening via statistical reasoning-augmented large language models using wearable and environmental data.Scientific reports · 2026Article
- Diagnosis of depression in adolescence signals improved inflammatory health in adulthood: Results from a nationally representative longitudinal study.Brain, behavior, and immunity · 2026Article
- Evaluation of primary care mental health integration and screening of anxiety and depression symptoms in Qatar from 2018 to 2023.Scientific reports · 2025Article
- Epigenetic profiles of response to transcranial magnetic stimulation in treatment resistant depression.BMC medical genomics · 2025Article
- Reimagining Resilience in Aging: Leveraging AI/ML, Big Data Analytics, and Systems Innovation.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- An examination of symptoms, function and quality of life as conjoint clinical outcome domains for treatment-resistant depression.Journal of mood and anxiety disorders · 2025Article
- Article
- Estimating the Sex Gap in Depression-Free Life Expectancy Among Widowed Americans Aged 50 and Older: An Application Using the Interpolated Markov Chain Approach.Journal of aging and health · 2025Article
- The moderating role of mindfulness in the relationship between loneliness and depressive symptoms.Scientific reports · 2024Article
- Review
- Article
- Telemental Health Utilization in Commercial Health Insurance Plans in the United States From 2010 Through 2019.The Journal of clinical psychiatry · 2023Article
- Depression in Diabetes-The Hidden Bane.Annals of neurosciences · 2023Article
- Systematic review and meta-analysis of performance of wearable artificial intelligence in detecting and predicting depression.NPJ digital medicine · 2023Article
- Wearable Artificial Intelligence for Anxiety and Depression: Scoping Review.Journal of medical Internet research · 2023Article
- Geriatric symptoms associated with healthy life expectancy in older people in Japan.Environmental health and preventive medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo estimate quality-adjusted life expectancy (QALE) loss among US adults due to depression and QALE losses associated with the increased risk of suicide attributable to depression.
methodWe ascertained depressive symptoms using the eight-item Patient Health Questionnaire (PHQ-8) on the 2006, 2008, and 2010 Behavioral Risk Factor Surveillance System (BRFSS) surveys. We estimated health-related quality of life (HRQOL) scores from BRFSS data (n = 276,442) and constructed life tables from US Compressed Mortality Files to calculate QALE by depression status. QALE loss due to depression is the difference in QALE between depressed and non-depressed adults. QALE loss associated with suicide deaths is the difference between QALE from only those deaths that did not have suicide recorded on the death certificate and QALE from all deaths including those with a suicide recorded on the death certificate.
resultsAt age 18, QALE was 28.0 more years for depressed adults and 56.8 more years for non-depressed adults, a 28.9-year QALE loss due to depression. For depressed adults, only 0.41 years of QALE loss resulted from deaths by suicide, and only 0.26 years of this loss could be attributed to depression.
conclusionDepression symptoms lead to a significant burden of disease from both mortality and morbidity as assessed by QALE loss. The 28.9-year QALE loss at age 18 associated with depression markedly exceeds estimates reported elsewhere for stroke (12.4-year loss), heart disease (10.3-year loss), diabetes mellitus (11.1-year loss), hypertension (6.3-year loss), asthma (7.0-year loss), smoking (11.0-year loss), and physical inactivity (8.0-year loss).
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