ArticleScientific reports2015
Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.
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51 citing papers in PubMed.
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- Mechanistic insights into isopropyl myristate-stimulated monascus pigment biosynthesis via untargeted metabolomics.World journal of microbiology & biotechnology · 2026Article
- Mechanistic Insights from Transcriptomics: How the Glucose TransporterJournal of fungi (Basel, Switzerland) · 2025Article
- From Artisan Experience to Scientific Elucidation: Preparation Processes, Microbial Diversity, and Food Applications of Chinese Traditional Fermentation Starters (Qu).Foods (Basel, Switzerland) · 2025Review
- Pigment Formation byJournal of agricultural and food chemistry · 2025Article
- Nutritional Value Improvement of Oats by Solid-State Fermentation withFoods (Basel, Switzerland) · 2025Article
- Transcriptome Analysis Revealed the Molecular Mechanism of Acetic Acid IncreasingJournal of fungi (Basel, Switzerland) · 2025Article
- Expanding the Toolbox for Genetic Manipulation inJournal of fungi (Basel, Switzerland) · 2024Article
- Article
- Genetic and Environmental Factors Influencing the Production of Select Fungal Colorants: Challenges and Opportunities in Industrial Applications.Journal of fungi (Basel, Switzerland) · 2023Review
- Current advances for omics-guided process optimization of microbial manufacturing.Bioresources and bioprocessing · 2023Review
- Fungal Pigments: Carotenoids, Riboflavin, and Polyketides with Diverse Applications.Journal of fungi (Basel, Switzerland) · 2023Review
- Mannitol improvesFrontiers in microbiology · 2023Article
- Insight into the phylogeny and metabolic divergence ofFrontiers in microbiology · 2023Article
- Production of Fungal Pigments: Molecular Processes and Their Applications.Journal of fungi (Basel, Switzerland) · 2022Review
- Selection for Translational Efficiency in Genes Associated with Alphaproteobacterial Gene Transfer Agents.mSystems · 2022Article
- Metabolomics Analysis Coupled with Weighted Gene Co-Expression Network Analysis Unravels the Associations of Tricarboxylic Acid Cycle-Intermediates with Edible Pigments Produced byFoods (Basel, Switzerland) · 2022Article
- Identification of the high-yield monacolin K strain from Monascus spp. and its submerged fermentation using different medicinal plants.Botanical studies · 2022Article
- Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids.Marine drugs · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monascus has been used to produce natural colorants and food supplements for more than one thousand years, and approximately more than one billion people eat Monascus-fermented products during their daily life. In this study, using next-generation sequencing and optical mapping approaches, a 24.1-Mb complete genome of an industrial strain, Monascus purpureus YY-1, was obtained. This genome consists of eight chromosomes and 7,491 genes. Phylogenetic analysis at the genome level provides convincing evidence for the evolutionary position of M. purpureus. We provide the first comprehensive prediction of the biosynthetic pathway for Monascus pigment. Comparative genomic analyses show that the genome of M. purpureus is 13.6-40% smaller than those of closely related filamentous fungi and has undergone significant gene losses, most of which likely occurred during its specialized adaptation to starch-based foods. Comparative transcriptome analysis reveals that carbon starvation stress, resulting from the use of relatively low-quality carbon sources, contributes to the high yield of pigments by repressing central carbon metabolism and augmenting the acetyl-CoA pool. Our work provides important insights into the evolution of this economically important fungus and lays a foundation for future genetic manipulation and engineering of this strain.
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