Evidence map›Paper›PMID 25660341›Full record

ArticlePhysiology & behavior2015

Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat.

Clare M Mathes, Ryan A Bohnenkamp, Ginger D Blonde, Chanel Letourneau, Caroline Corteville, Marco Bueter, Thomas A Lutz, Carel W le Roux, Alan C Spector

3 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03747445 completednot on this mapstarted 2018, after this paper: background citation

Microstructural Analysis of Ingestive Behavior After Roux-en-Y Gastric Bypass - a Prospective Controlled Exploratory Pilot Study Using a Novel Drinkometer to Measure Liquid Lunch Intake

TypeobservationalSponsorMarco BueterRan2018 to 2020Enrolled30ConditionsMeal, Obesity, Morbid, Food Deprivation, Bariatric SurgeryArmsRoux-en-Y gastric bypass
NCT04600596 completednot on this mapstarted 2019, after this paper: background citation

Adherence of Reporting Energy Intake by a Novel Food Photo Recognition Dietary Assessment App on Morbid Obese Subjects Scheduled for Bariatric Surgery

TypeobservationalSponsorMarco BueterRan2019 to 2023Enrolled54ConditionsObesity, Morbid, Bariatric Surgery, Roux-en-Y Gastric Bypass, Food PreferencesArmsRecording of food intake.
NCT04933305 completednot on this mapstarted 2019, after this paper: background citation

Correlation Between Microstructure of Ingestive Behavior and Body Weight Loss in Patients After Roux-en-Y Gastric Bypass

TypeobservationalSponsorMarco BueterRan2019 to 2021Enrolled50ConditionsObesity, Food Deprivation, Bariatric Surgery, Roux-en-y Gastric BypassArmsRoux-en-Y Gastric Bypass
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  16. Taste the Pain: The Role of TRP Channels in Pain and Taste Perception.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Clare M MathesDepartment of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL, USA.
Ryan A BohnenkampDepartment of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL, USA.
Ginger D BlondeDepartment of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL, USA.
Chanel LetourneauDepartment of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL, USA.
Caroline CortevilleInstitute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Switzerland.
Marco BueterInstitute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland.
Thomas A LutzInstitute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland; Institute of Laboratory Animal Science, Vetsuisse Faculty University of Zurich, Switzerland.
Carel W le RouxDiabetes Complications Research Centre, School of Medicine and Medical Science, University College Dublin, Ireland; Investigative Medicine, Imperial College London, UK; Gastrosurgical Laboratory, University of Gothenburg, Sweden.
Alan C SpectorDepartment of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL, USA. Electronic address: spector@psy.fsu.edu.
Florida State University · USUniversity of Zurich · CHUniversity College Dublin · IE

Funding

Motivational Changes for Nutritionally Relevant Tastes after Gastric BypassR21DC012751 · NIDCD · FLORIDA STATE UNIVERSITY · PI SPECTOR, ALAN C · 2012 to 2013
$389k
NIDCD NIH HHS R21 DC012751NIDCD NIH HHS R21-DC012751
6 · The paper itself

Abstract

After Roux-en-Y gastric bypass (RYGB) surgery, patients report consuming fewer fatty and dessert-like foods, and rats display blunted sugar and fat preferences. Here we used a progressive ratio (PR) task in our rat model to explicitly test whether RYGB decreases the willingness of rats to work for very small amounts of preferred sugar- and/or fat-containing fluids. In each of two studies, two groups of rats - one maintained on a high-fat diet (HFD) and standard chow (CHOW) and one given CHOW alone - were trained while water-deprived to work for water or either Ensure or 1.0M sucrose on increasingly difficult operant schedules. When tested before surgery while nondeprived, HFD rats had lower PR breakpoints (number of operant responses in the last reinforced ratio) for sucrose, but not for Ensure, than CHOW rats. After surgery, at no time did rats given RYGB show lower breakpoints than SHAM rats for Ensure, sucrose, or when 5% Intralipid served postoperatively as the reinforcer. Nevertheless, RYGB rats showed blunted preferences for these caloric fluids versus water in 2-bottle preference tests. Importantly, although the Intralipid and sucrose preferences of RYGB rats decreased further over time, subsequent breakpoints for them were not significantly impacted. Collectively, these data suggest that the observed lower preferences for normally palatable fluids after RYGB in rats may reflect a learned adjustment to altered postingestive feedback rather than a dampening of the reinforcing taste characteristics of such stimuli as measured by the PR task in which postingestive stimulation is negligible.

Indexed as

Appetitive BehaviorDietary FatsDietary SucroseEnergy IntakeFood PreferencesAnimal FeedAnimalsBody WeightConditioning, OperantDiet, High-FatDrinking WaterEmulsionsFood, FormulatedGastric BypassMaleModels, AnimalDietary FatsDietary SucroseDrinking WaterEmulsionsEnsure formulated foodPhospholipidsSoybean Oilsoybean oil, phospholipid emulsionBariatric surgeryMotivationOperant behaviorProgressive ratioReward

Identifiers

PMID25660341
PMCPMC4358755
OpenAlexW2038656944

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.