Evidence map›Paper›PMID 25660252›Full record

ArticleThe American journal of medicine2015

Use of osteoporosis medications after hospitalization for hip fracture: a cross-national study.

Seoyoung C Kim, Mi-Sook Kim, Gabriel Sanfélix-Gimeno, Hong Ji Song, Jun Liu, Isabel Hurtado, Salvador Peiró, Joongyub Lee, Nam-Kyong Choi, Byung-Joo Park and 1 more

Abstract read
In one paragraph

Article in The American journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Romosozumab or alendronate for fracture prevention in East Asian patients: a subanalysis of the phase III, randomized ARCH study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Trial
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  9. Contemporary pharmacological management of patients after hip fracture: a population-based cohort of over 120,000 patients in Spain.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  10. Article
  11. mSphere · 2025
    Article
  12. Article
  13. Frontiers in nutrition · 2025
    Article
  14. Article
  15. Secondary fracture prevention in primary care: a narrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Review
  16. Article
  17. Article
  18. Approach to the Patient With Bone Fracture: Making the First Fracture the Last.The Journal of clinical endocrinology and metabolism · 2023
    Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Seoyoung C KimDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Electronic address: skim62@partners.org.
Mi-Sook KimDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Gabriel Sanfélix-GimenoHealth Services Research Unit, Center for Public Health Research, Red de Investigación en Servicios de Salud en Enfermedades Crónicas, Valencia, Spain.
Hong Ji SongDepartment of Family Medicine, Health Promotion Center, Hallym University Sacred Heart Hospital, Anyang, Korea.
Jun LiuDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Isabel HurtadoHealth Services Research Unit, Center for Public Health Research, Red de Investigación en Servicios de Salud en Enfermedades Crónicas, Valencia, Spain.
Salvador PeiróHealth Services Research Unit, Center for Public Health Research, Red de Investigación en Servicios de Salud en Enfermedades Crónicas, Valencia, Spain.
Joongyub LeeMedical Research Collaborating Center, Seoul National University Hospital, Seoul, Korea.
Nam-Kyong ChoiMedical Research Collaborating Center, Seoul National University Hospital, Seoul, Korea.
Byung-Joo ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Korea Institute of Drug Safety and Risk Management, Seoul, Korea.
Jerry AvornDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

Funding

Cervical Dysplasia and Human Papillomavirus Infection in Rheumatoid Arthritis.K23AR059677 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KIM, SEOYOUNG CATHERINE · 2010 to 2014
$680k
NIAMS NIH HHS K23 AR059677
6 · The paper itself

Abstract

backgroundAlthough current osteoporosis management guidelines recommend use of pharmacologic treatment after hip fracture, the care of such patients has been suboptimal. The objective of this cross-national study was to quantify the use of and adherence to osteoporosis medication after hip fracture in 3 countries with different healthcare systems—the United States, Korea, and Spain.

methodsIn 3 cohorts of patients aged ≥65 years hospitalized for hip fracture, we calculated the proportion receiving ≥1 osteoporosis drug after discharge. Adherence to osteoporosis treatment was measured as the proportion of days covered (PDC) during the first year after the hip fracture.

resultsWe identified 86,202 patients with a hip fracture: 4704 (US Medicare), 6700 (US commercial), 57,631 (Korea), and 17,167 (Spain). The mean age was 77-83 years, and 74%-78% were women. In the year before the index hip fracture, 16%-18% were taking an osteoporosis medication. Within 3 months after the index hip fracture, 11% (US Medicare), 13% (US commercial), 39% (Korea), and 25% (Spain) of patients filled ≥1 prescription for osteoporosis medication. For those who filled ≥1 prescriptions for an osteoporosis medication, the mean PDC in the year after the fracture was 0.70 (US Medicare), 0.67 (US commercial), 0.43 (Korea), and 0.66 (Spain).

conclusionsRegardless of differences in healthcare delivery systems and medication reimbursement plans, the use of osteoporosis medications for the secondary prevention of osteoporotic fracture was low. Adherence to osteoporosis treatment was also suboptimal, with the PDC <0.70 in all 3 countries.

Indexed as

AgedAged, 80 and overBone Density Conservation AgentsComorbidityDiphosphonatesFemaleHip FracturesHospitalizationHumansMaleOsteoporotic FracturesRepublic of KoreaSecondary PreventionSpainUnited StatesBone Density Conservation AgentsDiphosphonatesAdherenceBisphosphonateCohort studyHip fractureOsteoporotic fracture

Identifiers

PMID25660252
PMCPMC4414898

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.