ArticleThe oncologist2015
M1 stage subdivision and treatment outcome of patients with bone-only metastasis of nasopharyngeal carcinoma.
Article in The oncologist, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- [European journal of nuclear medicine and molecular imaging · 2026Article
- Shoulder Pain Due to Humeral Metastasis: Unusual Presentation of Nasopharyngeal Carcinoma.Cureus · 2025Article
- Development and validation of a machine learning model for predicting 3-year overall survival in metastatic nasopharyngeal carcinoma: a SEER database and web visualization study.Translational cancer research · 2025Article
- Hip metastasis presenting as anterior knee pain from nasopharyngeal carcinoma: A case report.Oncology letters · 2025Article
- Efficacy of radiotherapy in treating local recurrence concomitant with distant metastasis of nasopharyngeal carcinoma: a long-term retrospective multicenter study.Clinical & experimental metastasis · 2025Article
- Article
- Anatomic prognostic factors and their potential roles in refining M1 classification for de novo metastatic nasopharyngeal carcinoma.Cancer medicine · 2023Article
- Anatomical Variants Identified on Computed Tomography of Oropharyngeal Carcinoma Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Skeletal scintigraphy as an important complement for detecting bone metastasis from nasopharyngeal carcinoma.The Journal of international medical research · 2022Article
- Identifying nasopharyngeal carcinoma patients with metachronous metastasis sensitive to local treatment: a real-world study.Journal of biomedical research · 2022Article
- A nonendemic analysis of the patterns and prognosis of de novo metastatic nasopharyngeal carcinomas in older patients aged ≥ 65 years.Scientific reports · 2022Article
- Article
- Optimal management of oligometastatic nasopharyngeal carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Review
- Radical resection for solitary thoracic spinous-process metastasis: a case report and technical note.Spinal cord series and cases · 2022Article
- Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study.Therapeutic advances in medical oncology · 2022Article
- Induction Chemotherapy Combined With Intensity-Modulated Radiotherapy for 129 Nasopharyngeal Carcinoma Patients With Synchronous Metastases: A Retrospective Study.Frontiers in oncology · 2021Article
- Investigation of the Definition of De Novo Oligometastatic Nasopharyngeal Carcinoma: A Retrospective Study.Journal of oncology · 2021Article
- Therapeutic Effect of Chemotherapy Cycle in Nasopharyngeal Carcinoma (NPC) Patients Who Developed Bone-Only Metastasis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based study.Annals of translational medicine · 2020Article
- Surgical Treatment Outcomes of Spinal Metastases of Nasopharyngeal Carcinoma: The First Report of 30 Patients from a Single Center.Cancer management and research · 2020Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe current M1 stage in nasopharyngeal carcinoma (NPC) does not differentiate patients based on metastatic site and number of metastases. This study aims to subdivide the M1 stage of NPC patients with bone-only metastases and to identify the patients who may benefit from combined chemoradiotherapy (CRT).
methodsBetween 1998 and 2007, 312 patients diagnosed with bone-only metastasis at Sun Yat-sen University Cancer Center were enrolled. Various possible subdivisions of M1 stage were considered, including by the time order of metastasis (synchronous vs. metachronous), involvement of specific bone metastatic site, the number of metastatic sites, and the number of metastases. The correlation of the subdivisions of M1 stage with overall survival (OS) was determined by Cox regression.
resultsThe median OS was 23.4 months. Patients with more than three metastatic sites had significantly poorer OS than patients with three or fewer metastatic sites (16.2 vs. 32.4 months; p < .001). Metastasis to the spine was significantly associated with unfavorable OS (20.4 vs. 37.9 months; p < .001). Multivariate analysis showed that number of metastatic sites (more than three vs. three or fewer), spine involvement (present vs. absent), and treatment modality (CRT vs. chemotherapy or radiotherapy only) were independent prognostic factors for OS. In stratified analysis, compared with chemotherapy or radiotherapy alone, combined chemoradiotherapy could significantly benefit the patients with single bone metastasis (hazard ratio: 0.21; 95% confidence interval: 0.09-0.50).
conclusionMetastasis to the spine and having more than three bone metastatic sites are independent unfavorable predictors for OS in NPC patients with bone-only metastasis. Combined chemoradiotherapy should be considered for patients with single bone metastasis.
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