Evidence map›Paper›PMID 25659919›Full record

SynthesisPsychosomatics

Toxicities associated with NBOMe ingestion-a novel class of potent hallucinogens: a review of the literature.

Joji Suzuki, Michael A Dekker, Erin S Valenti, Fabiola A Arbelo Cruz, Ady M Correa, Justin L Poklis, Alphonse Poklis

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychosomatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 123 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
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  9. Article
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  11. Article
  12. Review
  13. Article
  14. Effect ofFrontiers in psychiatry · 2022
    Article
  15. SEVERE ACUTE TOXIC EXPOSURES IN CHILDREN AND ADOLESCENTS: CASE SERIES.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2021
    Article
  16. Zebrafish andToxicology reports · 2021
    Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Joji SuzukiDepartment of Psychiatry, Brigham and Women׳s Hospital, Boston, MA (JS); Harvard Medical School, Boston, MA (JS, ESV). Electronic address: jsuzuki2@partners.org.
Michael A DekkerSouthern Arizona VA Healthcare System, Tucson, AZ (MAD).
Erin S ValentiHarvard Medical School, Boston, MA (JS, ESV); Harvard Longwood Psychiatry Residency Training Program, Boston, MA (ESV).
Fabiola A Arbelo CruzPonce School of Medicine and Health Sciences, Ponce, PR (FAAC, AMC).
Ady M CorreaPonce School of Medicine and Health Sciences, Ponce, PR (FAAC, AMC).
Justin L PoklisDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA (JLP).
Alphonse PoklisDepartment of Pathology, Virginia Commonwealth University, Richmond, VA (AP).
Harvard University · USPonce Health Sciences University · PRVirginia Commonwealth University · USSouthern Arizona VA Health Care System · US

Funding

VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Matthew Sean Halquist · 2014 to 2026
$13.8M
NIDA NIH HHS P30 DA033934
6 · The paper itself

Abstract

backgroundA new class of synthetic hallucinogens called NBOMe has emerged as drugs of abuse.

objectiveOur aim was to conduct a systematic review of published reports of toxicities associated with NBOMe ingestion.

methodsWe searched PubMed for relevant English-language citations that described adverse effects from analytically confirmed human NBOMe ingestion. Demographic and clinical data were extracted.

resultsA total of 10 citations met the criteria for inclusion, representing 20 individual patients. 25I-NBOMe was the most common analogue identified, followed by 25B-NBOMe and 25C-NBOMe. Fatalities were reported in 3 (15%) cases. Of all the patients, 7 (35%) were discharged after a period of observation, whereas 8 (40.0%) required admission to an intensive care unit. The most common adverse effects were agitation (85.0%), tachycardia (85.0%), and hypertension (65.0%). Seizures were reported in 8 (40.0%) patients. The most common abnormalities reported on laboratory tests were elevated level of creatinine kinase (45.0%), leukocytosis (25.0%), and hyperglycemia (20.0%).

conclusionNBOMe ingestion is associated with severe adverse effects. Clinicians need to have a high index of suspicion for NBOMe ingestion in patients reporting the recent use of hallucinogens.

Indexed as

AnisolesBenzylaminesCreatine KinaseDimethoxyphenylethylamineHallucinogensHumansHyperglycemiaHypertensionLeukocyte CountLeukocytosisPhenethylaminesSeizuresTachycardia2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine2-(4-chloro-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamineAnisolesBenzylaminesCreatine KinaseDimethoxyphenylethylamineHallucinogensPhenethylamines

Identifiers

PMID25659919
PMCPMC4355190
OpenAlexW2086829826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.