ArticleAmerican journal of physiology. Lung cellular and molecular physiology2015
Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure.
Article in American journal of physiology. Lung cellular and molecular physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2018Guideline
- Effect of estrogen receptor α on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Respiratory responses to hypoxia during rest and exercise in individuals born pre-term: a state-of-the-art review.European journal of applied physiology · 2022Review
- Exercise and hypoxia unmask pulmonary vascular disease and right ventricular dysfunction in a 10- to 12-week-old swine model of neonatal oxidative injury.The Journal of physiology · 2022Article
- Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation.JCI insight · 2022Article
- Exaggerated Cardiac Contractile Response to Hypoxia in Adults Born Preterm.Journal of clinical medicine · 2021Article
- Taking it to heart: dissecting cardiopulmonary interactions in diseases of the lung and the cardiovascular system.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Transcriptomic modifications in developmental cardiopulmonary adaptations to chronic hypoxia using a murine model of simulated high-altitude exposure.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Exogenous Estrogen Preserves Distal Pulmonary Arterial Mechanics and Prevents Pulmonary Hypertension in Rats.American journal of respiratory and critical care medicine · 2020Article
- Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart.American journal of physiology. Heart and circulatory physiology · 2019Article
- Impact of hyperoxia on cardiac pathophysiology.Journal of cellular physiology · 2019Review
- Pulmonary vascular mechanical consequences of ischemic heart failure and implications for right ventricular function.American journal of physiology. Heart and circulatory physiology · 2019Article
- Long-term pulmonary vascular consequences of perinatal insults.The Journal of physiology · 2019Review
- Exercise Overrides Blunted Hypoxic Ventilatory Response in Prematurely Born Men.Frontiers in physiology · 2019Article
- Early Pulmonary Vascular Disease in Young Adults Born Preterm.American journal of respiratory and critical care medicine · 2018Article
- Multiscale structure-function relationships in right ventricular failure due to pressure overload.American journal of physiology. Heart and circulatory physiology · 2018Article
- Health Disparities in Patients with Pulmonary Arterial Hypertension: A Blueprint for Action. An Official American Thoracic Society Statement.American journal of respiratory and critical care medicine · 2017Review
- Cumulative effects of neonatal hyperoxia on murine alveolar structure and function.Pediatric pulmonology · 2017Article
- Postnatal Hyperoxia Exposure Durably Impairs Right Ventricular Function and Mitochondrial Biogenesis.American journal of respiratory cell and molecular biology · 2017Article
- Addressing the challenges of phenotyping pediatric pulmonary vascular disease.Pulmonary circulation · 2017Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
The development of pulmonary hypertension (PH) requires multiple pulmonary vascular insults, yet the role of early oxygen therapy as an initial pulmonary vascular insult remains poorly defined. Here, we employ a two-hit model of PH, utilizing postnatal hyperoxia followed by adult hypoxia exposure, to evaluate the role of early hyperoxic lung injury in the development of later PH. Sprague-Dawley pups were exposed to 90% oxygen during postnatal days 0-4 or 0-10 or to room air. All pups were then allowed to mature in room air. At 10 wk of age, a subset of rats from each group was exposed to 2 wk of hypoxia (Patm = 362 mmHg). Physiological, structural, and biochemical endpoints were assessed at 12 wk. Prolonged (10 days) postnatal hyperoxia was independently associated with elevated right ventricular (RV) systolic pressure, which worsened after hypoxia exposure later in life. These findings were only partially explained by decreases in lung microvascular density. Surprisingly, postnatal hyperoxia resulted in robust RV hypertrophy and more preserved RV function and exercise capacity following adult hypoxia compared with nonhyperoxic rats. Biochemically, RVs from animals exposed to postnatal hyperoxia and adult hypoxia demonstrated increased capillarization and a switch to a fetal gene pattern, suggesting an RV more adept to handle adult hypoxia following postnatal hyperoxia exposure. We concluded that, despite negative impacts on pulmonary artery pressures, postnatal hyperoxia exposure may render a more adaptive RV phenotype to tolerate late pulmonary vascular insults.
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