ArticleNeurobiology of aging2015
Age differences in periventricular and deep white matter lesions.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Progressive White Matter Changes in Mitochondrial Disease: A Quantitative MRI Study.JIMD reports · 2026Article
- Heart-Brain Axis: Subclinical Cardiovascular Changes and Brain Health.Journal of the American Heart Association · 2026Review
- Patent foramen ovale is associated with white matter hyperintensities in young adults: a case-control study.Frontiers in neurology · 2026Article
- Impact of white matter hyperintensities on α4β2 nicotinic acetylcholine receptor binding in the human brain.European journal of nuclear medicine and molecular imaging · 2025Article
- Deep Learning Analysis of White Matter Hyperintensity and its Association with Comprehensive Vascular Factors in Two Large General Populations.Journal of imaging informatics in medicine · 2025Article
- Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals.Neurobiology of aging · 2025Article
- Connecting the dots: microstructural properties of white matter hyperintensities predict longitudinal cognitive changes in ageing.Frontiers in aging neuroscience · 2025Article
- The ageing central nervous system in multiple sclerosis: the imaging perspective.Brain : a journal of neurology · 2024Review
- The impact of cerebral small vessel disease burden on prognosis in patients with acute coronary syndrome.Journal of geriatric cardiology : JGC · 2024Article
- The relationship between intracranial atherosclerosis and white matter hyperintensity in ischemic stroke patients: a retrospective cross-sectional study using high-resolution magnetic resonance vessel wall imaging.Quantitative imaging in medicine and surgery · 2024Article
- A multiphysics model to predict periventricular white matter hyperintensity growth during healthy brain aging.Brain multiphysics · 2023Article
- White Matter Hyperintensities in Young Patients from a Neurological Outpatient Clinic: Prevalence, Risk Factors, and Correlation with Enlarged Perivascular Spaces.Journal of personalized medicine · 2023Article
- 3D finite-element brain modeling of lateral ventricular wall loading to rationalize periventricular white matter hyperintensity locations.Engineering with computers · 2022Article
- Obstructive sleep apnea and white matter hyperintensities: correlation or causation?Brain imaging and behavior · 2022Article
- Use of proton pump inhibitor may be associated with progression of cerebral small vessel disease.PloS one · 2022Article
- Brain aging mechanisms with mechanical manifestations.Mechanisms of ageing and development · 2021Review
- Article
- MTT and Blood-Brain Barrier Disruption within Asymptomatic Vascular WM Lesions.AJNR. American journal of neuroradiology · 2021Article
- White Matter Lesions as Possible Predictors of Audiological Performance in Adults after Cochlear Implantation.Brain sciences · 2021Article
- Cerebral Small-Vessel Disease in Individuals with a Family History of Coronary Heart Disease: The Atherosclerosis Risk in Communities Study.Neuroepidemiology · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Deep white matter hyperintensity (DWMH) and periventricular (PV) white matter lesion volumes are associated with age and subsequent stroke. We studied age differences in these volumes accounting for collinearity and risk factors. Subjects were 563 healthy family members of early-onset coronary artery disease patients. Using 3T magnetic resonance imaging, lesions were classified as DWMH or PV. Age association with lesion classification was analyzed using random effects Tobit regression, adjusting for intracranial volume (ICV) and risk factors. Subjects were 60% women, 36% African-American, mean age 51 ± 11 years. In multivariable analysis adjusted for PV and ICV, DWMH was associated with age (p < 0.001) and female sex (p = 0.003). PV, adjusted for DWMH and ICV, was age associated (p < 0.001). For each age decade, DWMH showed 0.07 log units/decade greater volume (95% CI = 0.04-0.11); PV was 0.18 log units/decade greater (95% CI = 0.14-0.23); slope differences (p < 0.001). In people with a family history of coronary artery disease, PV and DWMH are independently and differentially associated with age controlling for traditional risk factors.
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Registered trials
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