Evidence map›Paper›PMID 25659473›Full record

ArticlePsychiatry research2015

Orbitofrontal cortex, emotional decision-making and response to cognitive behavioural therapy for psychosis.

Preethi Premkumar, Dominic Fannon, Adegboyega Sapara, Emmanuelle R Peters, Anantha P Anilkumar, Andrew Simmons, Elizabeth Kuipers, Veena Kumari

Abstract read
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In one paragraph

Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Neuroimaging in Schizophrenia.Neuroimaging clinics of North America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Preethi PremkumarDivision of Psychology, School of Social Sciences, Nottingham Trent University, Nottingham, UK. Electronic address: Preethi.premkumar@ntu.ac.uk.
Dominic FannonDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King׳s College London, London, UK.
Adegboyega SaparaDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King׳s College London, London, UK.
Emmanuelle R PetersDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King׳s College London, London, UK; NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London, UK.
Anantha P AnilkumarSouth London and Maudsley NHS Foundation Trust, London, UK.
Andrew SimmonsNIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King׳s College London, UK.
Elizabeth KuipersDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King׳s College London, London, UK; NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London, UK.
Veena KumariDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King׳s College London, London, UK; NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London, UK.

Funding

Wellcome Trust 067427/z/02/z
6 · The paper itself

Abstract

Grey matter volume (GMV) in the orbitofrontal cortex (OFC) may relate to better response to cognitive behavioural therapy for psychosis (CBTp) because of the region׳s role in emotional decision-making and cognitive flexibility. This study aimed to determine the relation between pre-therapy OFC GMV or asymmetry, emotional decision-making and CBTp responsiveness. Emotional decision-making was measured by the Iowa Gambling task (IGT). Thirty patients received CBTp+standard care (CBTp+SC; 25 completers) for 6-8 months. All patients (before receiving CBTp) and 25 healthy participants underwent structural magnetic resonance imaging. Patients׳ symptoms were assessed before and after therapy. Pre-therapy OFC GMV was measured using a region-of-interest approach, and IGT performance was measured as overall learning, attention to reward, memory for past outcomes and choice consistency. Both these measures, were comparable between patient and healthy groups. In the CBTp+SC group, greater OFC GMV correlated with positive symptom improvement, specifically hallucinations and persecution. Greater rightward OFC asymmetry correlated with improvement in several negative and general psychopathology symptoms. Greater left OFC GMV was associated with lower IGT attention to reward. The findings suggest that greater OFC volume and rightward asymmetry, which maintain the OFC׳s function in emotional decision-making and cognitive flexibility, are beneficial for CBTp responsiveness.

Indexed as

AdultCognitive Behavioral TherapyDecision MakingEmotionsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPrefrontal CortexPsychotic DisordersSchizophreniaTreatment OutcomeYoung AdultAsymmetryPrefrontal cortexSchizophrenia

Identifiers

PMID25659473
PMCPMC4834460

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.