Evidence map›Paper›PMID 25659437›Full record

ArticleThe American journal of case reports2015

Brain abscess following rituximab infusion in a patient with pemphigus vulgaris.

Talal M Al-Harbi, Shahad A Al-Muammar, Ronald J Ellis

Abstract readCase Reports
In one paragraph

Article in The American journal of case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Talal M Al-HarbiDepartment of Neurology, Neuroscience Centre, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Shahad A Al-MuammarDepartment of Neurology, Neuroscience Centre, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Ronald J EllisDepartment of Neuroscience, University of California, San Diego, CA, USA.
King Fahad Specialist Hospital · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunocompromised patients are at increased risk for developing meningitis or, rarely, brain abscess with opportunistic organisms like Listeria monocytogenes. CASE REPORT: A 52 year-old Saudi Arabian woman who was diagnosed with pemphigus vulgaris and diabetes and had been on prednisolone and azathioprine for about 4 years. She presented with headache, low-grade fever, and left-sided weakness 2 weeks after receiving the second dose of rituximab infusion. Magnetic resonance imaging revealed an enhanced space-occupying lesion with multiple small cyst-like structures and vasogenic edema in the right temporoparietal area. Her blood culture was positive for Listeria monocytogenes, and a brain biopsy showed necrotic tissues with pus and inflammatory cells. She recovered after a 6-week course of antibiotics with ampicillin and gentamycin.

conclusionsBrain abscess due to Listeria monocytogenes is a risk that should be considered when adding rituximab to the regimen of a patient who is already Immunocompromised.

Indexed as

Antibodies, Monoclonal, Murine-DerivedAntigens, CD20Brain AbscessFemaleHumansImmunologic FactorsInfusions, IntravenousMagnetic Resonance ImagingMiddle AgedPemphigusRituximabAntibodies, Monoclonal, Murine-DerivedAntigens, CD20Immunologic FactorsRituximab

Identifiers

PMID25659437
PMCPMC4332264
OpenAlexW2007973860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.